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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 Hits 1 – 20 of 28 1 Tractography of supplementary motor area projections in progressive speech apraxia and aphasia Valls Carbo, Adrian; Reid, Robert I.; Tosakulwong, Nirubol... In: Neuroimage Clin (2022) BASE Show details 2 A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech Josephs, Keith A.; Duffy, Joseph R.; Clark, Heather M.... In: Nat Commun (2021) BASE Show details 3 Association of amyloid angiopathy with microbleeds in logopenic progressive aphasia: an imaging-pathology study Buciuc, Marina; Duffy, Joseph R.; Machulda, Mary M.... In: Eur J Neurol (2020) BASE Show details 4 Longitudinal anatomic, functional, and molecular characterization of Pick disease phenotypes Whitwell, Jennifer L.; Tosakulwong, Nirubol; Schwarz, Christopher C.... In: Neurology (2020) BASE Show details 5 Clinical and Neuroimaging Characteristics of Clinically Unclassifiable Primary Progressive Aphasia Utianski, Rene L.; Botha, Hugo; Martin, Peter R.... In: Brain Lang (2019) BASE Show details 6 The influence of β-amyloid on [(18)F]AV-1451 in semantic variant of primary progressive aphasia Whitwell, Jennifer L.; Martin, Peter R.; Duffy, Joseph R.. - : Lippincott Williams & Wilkins, 2019 BASE Show details 7 [18F]AV-1451 tau-PET and primary progressive aphasia Josephs, Keith A.; Martin, Peter R.; Botha, Hugo. - 2018 BASE Show details 8 Tau Uptake in Agrammatic Primary Progressive Aphasia with and without Apraxia of Speech Utianski, Rene L.; Whitwell, Jennifer L.; Schwarz, Christopher G.. - 2018 BASE Show details 9 Disrupted functional connectivity in primary progressive apraxia of speech Botha, Hugo; Utianski, Rene L.; Whitwell, Jennifer L.. - : Elsevier, 2018 BASE Show details 10 Tau-PET imaging with [18F]AV-1451 in Primary Progressive Apraxia of Speech Utianski, Rene L.; Whitwell, Jennifer L.; Schwarz, Christopher G.; Senjem, Matthew L.; Tosakulwong, Nirubol; Duffy, Joseph R.; Clark, Heather M.; Machulda, Mary M.; Petersen, Ronald C.; Jack, Clifford R.; Lowe, Val J.; Josephs, Keith A.. - 2018 Abstract: Apraxia of speech is a motor speech disorder characterized by combinations of slow speaking rate, abnormal prosody, distorted sound substitutions, and trial-and-error articulatory movements. Apraxia of speech is due to abnormal planning and/or programming of speech production. It is referred to as primary progressive apraxia of speech (PPAOS) when it is the only symptom of a neurodegenerative condition. Past reports suggest an association of PPAOS with primary 4-repeat (4R) tau (e.g. progressive supranuclear palsy, corticobasal degeneration), rather than amyloid, pathology. The goal of the current study was to investigate the distribution of tau tracer uptake using [18F]AV-1451 positron emission tomography (PET) imaging in patients with PPAOS. Fourteen PPAOS patients underwent [18F]AV-1451 PET (tau-PET) imaging, [C11] Pittsburgh Compound B (PiB) PET and structural MRI and were matched 3:1 by age and sex to 42 cognitively normal controls. Tau-PET uptake was assessed at the region-of-interest (ROI) level and at the voxel-level. The PPAOS group (n=14) showed increased tau-PET uptake in the precentral gyrus, supplementary motor area and Broca’s area compared to controls. To examine whether tau deposition in Broca’s area was related to the presence of aphasia, we examined a subgroup of the PPAOS patients who had predominant apraxia of speech, with concomitant aphasia (PPAOSa; n = 7). The PPAOSa patients showed tau-PET uptake in the same regions as the whole group. However, the remaining seven patients who did not have aphasia showed uptake only in superior premotor and precentral cortices, with no uptake observed in Broca’s area. This cross-sectional study demonstrates that elevated tau tracer uptake is observed using [18F]AV-1451 in PPAOS. Further, it appears that [18F]AV-1451 is sensitive to the regional distribution of tau deposition in different stages of PPAOS, given the relationship between tau signal in Broca’s area and the presence of aphasia. Keyword: Article URL: https://doi.org/10.1016/j.cortex.2017.12.021 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800944/ http://www.ncbi.nlm.nih.gov/pubmed/29353121 BASE Hide details 11 Prosodic and Phonetic Subtypes of Primary Progressive Apraxia of Speech Utianski, Rene L.; Duffy, Joseph R.; Clark, Heather M.. - 2018 BASE Show details 12 Predicting clinical decline in progressive agrammatic aphasia and apraxia of speech Whitwell, Jennifer L.; Weigand, Stephen D.; Duffy, Joseph R.. - : Lippincott Williams & Wilkins, 2017 BASE Show details 13 Varying degrees of temporoparietal hypometabolism on FDG-PET reveal amyloid-positive logopenic primary progressive aphasia is not a homogeneous clinical entity Krishnan, Kamini; Machulda, Mary M.; Whitwell, Jennifer L.. - 2017 BASE Show details 14 Tracking the Development of Agrammatic Aphasia: a Tensor-Based Morphometry Study Whitwell, Jennifer L.; Duffy, Joseph R.; Machulda, Mary M.. - 2016 BASE Show details 15 Clinical and MRI models predicting amyloid deposition in progressive aphasia and apraxia of speech Whitwell, Jennifer L.; Weigand, Stephen D.; Duffy, Joseph R.. - : Elsevier, 2016 BASE Show details 16 Clinical and neuroimaging biomarkers of amyloid-negative logopenic primary progressive aphasia Whitwell, Jennifer L.; Duffy, Joseph R.; Strand, Edythe A.. - 2015 BASE Show details 17 Classification and clinicoradiologic features of primary progressive aphasia (PPA) and apraxia of speech Botha, Hugo; Duffy, Joseph R.; Whitwell, Jennifer L.. - 2015 BASE Show details 18 Regional β-amyloid burden does not correlate with cognitive or language deficits in Alzheimer’s disease presenting as aphasia Jung, Youngsin; Whitwell, Jennifer L.; Duffy, Joseph R.. - 2015 BASE Show details 19 Progranulin-associated PiB-negative logopenic primary progressive aphasia Josephs, Keith A.; Duffy, Joseph R.; Strand, Edythe A.. - 2014 BASE Show details 20 Working memory and language network dysfunction in logopenic aphasia: a task-free fMRI comparison to Alzheimer’s dementia Whitwell, Jennifer L.; Jones, David T.; Duffy, Joseph R.. - 2014 BASE Show details Page: 1 2

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