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1	Auditory processing deficits in individuals with primary open-angle glaucoma.
	Rance, Gary; O'Hare, Fleur; O'Leary, Stephen; Starr, Arnold; Ly, Anna; Cheng, Belinda; Tomlin, Dani; Graydon, Kelley; Chisari, Donella; Trounce, Ian; Crowston, Jonathan
	In: International journal of audiology, vol 51, iss 1 (2012)
	Abstract: ObjectiveThe high energy demand of the auditory and visual pathways render these sensory systems prone to diseases that impair mitochondrial function. Primary open-angle glaucoma, a neurodegenerative disease of the optic nerve, has recently been associated with a spectrum of mitochondrial abnormalities. This study sought to investigate auditory processing in individuals with open-angle glaucoma. DESIGN/STUDY SAMPLE: Twenty-seven subjects with open-angle glaucoma underwent electrophysiologic (auditory brainstem response), auditory temporal processing (amplitude modulation detection), and speech perception (monosyllabic words in quiet and background noise) assessment in each ear. A cohort of age, gender and hearing level matched control subjects was also tested.ResultsWhile the majority of glaucoma subjects in this study demonstrated normal auditory function, there were a significant number (6/27 subjects, 22%) who showed abnormal auditory brainstem responses and impaired auditory perception in one or both ears.ConclusionsThe finding that a significant proportion of subjects with open-angle glaucoma presented with auditory dysfunction provides evidence of systemic neuronal susceptibility. Affected individuals may suffer significant communication difficulties in everyday listening situations.
	Keyword: Acoustic Stimulation; Aged; Audiometry; Auditory; Auditory neuropathy; Auditory Pathways; Auditory Perception; Auditory processing; Auditory Threshold; Brain Stem; Case-Control Studies; Clinical Sciences; Electroencephalography; Evoked Potentials; Female; Glaucoma; Humans; Male; Middle Aged; Mitochondria; Noise; Open-Angle; Otorhinolaryngology; Perceptual Masking; Reaction Time; Speech Perception; Temporal resolution; Time Factors; Time Perception; Victoria; Visual Acuity
	URL: https://escholarship.org/uc/item/4h36f50d
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