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1
Predictors of reading and spelling skills in German: The role of morphological awareness
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2
Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia
In: ISSN: 1359-4184 ; EISSN: 1476-5578 ; Molecular Psychiatry ; https://hal.archives-ouvertes.fr/hal-02976104 ; Molecular Psychiatry, Nature Publishing Group, 2020, ⟨10.1038/s41380-020-00898-x⟩ (2020)
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3
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
In: ISSN: 2158-3188 ; EISSN: 2158-3188 ; Translational Psychiatry ; https://hal.archives-ouvertes.fr/hal-02158502 ; Translational Psychiatry, Nature Pub. Group, 2019, 9, pp.77. ⟨10.1038/s41398-019-0402-0⟩ (2019)
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia ...
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5
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
In: Translational Psychiatry, 9 (1) (2019)
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6
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
Abstract: A.G. and T.F.M.A. were supported by the Munich Cluster for Systems Neurology (SyNergy). S.P. is a Royal Society University research Fellow. B.M.M., C.F., B.S.P., and S.E.F. are supported by the Max Planck Society. A.P.M. is a Wellcome Senior Fellow in Basic Biomedical Science (WT098017). F.R. is supported by Agence Nationale de la Recherche (ANR-06-NEURO-019-01, ANR-10-LABX-0087 IEC, ANR-10-IDEX-0001-02 PSL, ANR-11-BSV4-014-01), European Commission (LSHM-CT-2005-018696), Ville de Paris. ; Developmental dyslexia (DD) is one of the most prevalent learning disorders, with high impact on school and psychosocial development and high comorbidity with conditions like attention-deficit hyperactivity disorder (ADHD), depression, and anxiety. DD is characterized by deficits in different cognitive skills, including word reading, spelling, rapid naming, and phonology. To investigate the genetic basis of DD, we conducted a genome-wide association study (GWAS) of these skills within one of the largest studies available, including nine cohorts of reading-impaired and typically developing children of European ancestry (N = 2562–3468). We observed a genome-wide significant effect (p < 1 × 10−8) on rapid automatized naming of letters (RANlet) for variants on 18q12.2, within MIR924HG (micro-RNA 924 host gene; rs17663182 p = 4.73 × 10−9), and a suggestive association on 8q12.3 within NKAIN3 (encoding a cation transporter; rs16928927, p = 2.25 × 10−8). rs17663182 (18q12.2) also showed genome-wide significant multivariate associations with RAN measures (p = 1.15 × 10−8) and with all the cognitive traits tested (p = 3.07 × 10−8), suggesting (relational) pleiotropic effects of this variant. A polygenic risk score (PRS) analysis revealed significant genetic overlaps of some of the DD-related traits with educational attainment (EDUyears) and ADHD. Reading and spelling abilities were positively associated with EDUyears (p ~ [10−5–10−7]) and negatively associated with ADHD PRS (p ~ [10−8−10−17]). This corroborates a long-standing hypothesis on the partly shared genetic etiology of DD and ADHD, at the genome-wide level. Our findings suggest new candidate DD susceptibility genes and provide new insights into the genetics of dyslexia and its comorbities. ; Publisher PDF ; Peer reviewed
Keyword: BDC; DAS; QH301; QH301 Biology; R2C; RC0321; RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry; RJ; RJ Pediatrics; ~DC~
URL: https://doi.org/10.1038/s41398-019-0402-0
http://hdl.handle.net/10023/17043
https://www.biorxiv.org/content/early/2018/05/02/309336
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7
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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8
White matter alterations and tract lateralization in children with dyslexia and isolated spelling deficits
Banfi, Chiara; Koschutnig, Karl; Moll, Kristina. - : John Wiley & Sons, Inc., 2018
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9
Orthographic learning in children with isolated and combined reading and spelling deficits
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10
Deficits in Letter-Speech Sound Associations but Intact Visual Conflict Processing in Dyslexia: Results from a Novel ERP-Paradigm
In: Frontiers in Human Neuroscience (2017)
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11
Visuo-spatial cueing in children with differential reading and spelling profiles
In: PLOS One (2017)
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12
Deficits in Letter-Speech Sound Associations but Intact Visual Conflict Processing in Dyslexia: Results from a Novel ERP-Paradigm
Bakos, Sarolta; Landerl, Karin; Bartling, Jürgen. - : Frontiers Media S.A., 2017
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13
Visuo-spatial cueing in children with differential reading and spelling profiles
Banfi, Chiara; Kemény, Ferenc; Gangl, Melanie. - : Public Library of Science, 2017
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14
Lexical Reading in Dysfluent Readers of German
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15
Predictors of developmental dyslexia in European orthographies with varying complexity.
In: ISSN: 0021-9630 ; EISSN: 1469-7610 ; Journal of Child Psychology and Psychiatry ; https://hal.archives-ouvertes.fr/hal-00965034 ; Journal of Child Psychology and Psychiatry, Wiley, 2013, 54 (6), pp.686-94. &#x27E8;10.1111/jcpp.12029&#x27E9; (2013)
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