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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 4 of 4 1 Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills Yu, Xi; Zuk, Jennifer; Perdue, Meaghan V.... In: Wiley (2021) BASE Show details 2 Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills Yu, Xi; Zuk, Jennifer; Perdue, Meaghan V.; Ozernov-Palchik, Ola; Raney, Talia; Beach, Sara Dawley; Norton, Elizabeth S.; Ou, Yangming; Gabrieli, John D. E.; Gaab, Nadine In: Wiley (2021) Abstract: Human Brain Mapping published by Wiley Periodicals, Inc. Developmental dyslexia affects 40–60% of children with a familial risk (FHD+) compared to a general prevalence of 5–10%. Despite the increased risk, about half of FHD+ children develop typical reading abilities (FHD+Typical). Yet the underlying neural characteristics of favorable reading outcomes in at-risk children remain unknown. Utilizing a retrospective, longitudinal approach, this study examined whether putative protective neural mechanisms can be observed in FHD+Typical at the prereading stage. Functional and structural brain characteristics were examined in 47 FHD+ prereaders who subsequently developed typical (n = 35) or impaired (n = 12) reading abilities and 34 controls (FHD−Typical). Searchlight-based multivariate pattern analyses identified distinct activation patterns during phonological processing between FHD+Typical and FHD−Typical in right inferior frontal gyrus (RIFG) and left temporo-parietal cortex (LTPC) regions. Follow-up analyses on group-specific classification patterns demonstrated LTPC hypoactivation in FHD+Typical compared to FHD−Typical, suggesting this neural characteristic as an FHD+ phenotype. In contrast, RIFG showed hyperactivation in FHD+Typical than FHD−Typical, and its activation pattern was positively correlated with subsequent reading abilities in FHD+ but not controls (FHD−Typical). RIFG hyperactivation in FHD+Typical was further associated with increased interhemispheric functional and structural connectivity. These results suggest that some protective neural mechanisms are already established in FHD+Typical prereaders supporting their typical reading development. ; National Institute of Child Health and Human Development (Awards R01HD067312 and R01HD65762‐01) URL: https://hdl.handle.net/1721.1/130434.2 BASE Hide details 3 Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills Yu, Xi; Zuk, Jennifer; Perdue, Meaghan V.. - 2020 BASE Show details 4 Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills Yu, Xi; Zuk, Jennifer; Perdue, Meaghan V.... In: Hum Brain Mapp (2020) BASE Show details

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