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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 3 of 3 1 Cerebrospinal Fluid Tau, p-Tau 181 and Amyloid-beta(38/40/42) in Frontotemporal Dementias and Primary Progressive Aphasias Bibl, Mirko; Mollenhauer, Brit; Lewczuk, Piotr; Esselmann, Hermann; Wolf, Stefanie; Otto, Markus; Kornhuber, Johannes; Rüther, Eckart; Wiltfang, Jens In: Dementia and Geriatric Cognitive Disorders (2011) Abstract: Background/Aims: We determined cerebrospinal fluid (CSF) concentrations of amyloid-beta(A beta)(1-38), A beta(1-40), A beta(1-42), total tau and phospho-tau (p-tau) in order to study their differential expression in frontotemporal dementia (FTD, n = 25) and primary progressive aphasia (PPA, n = 12) as compared to Alzheimer's dementia (AD, n = 25) and nondemented controls (n = 20). Methods: Commercially available ELISA and electrochemiluminescence methods were applied. Results: High CSF p-tau and low ratios of A beta(1-42)/A beta(1-40) and A beta(1-42)/A beta(1-38), respectively, were specific for AD. CSF A beta(1-38) was reduced in FTD as compared to each of the other diagnostic groups, including PPA. CSF tau and p-tau levels were elevated in PPA as compared to FTD. Conclusion: This is the first detailed report on biomarker patterns in PPA, indicating distinct CSF biomarker patterns in FTD and PPA as major subgroups of frontotemporal lobar degeneration. The diagnostic and pathophysiological implications of our results warrant further studies on larger and neuropathologically diagnosed patient populations. Copyright (C) 2010 S. Karger AG, Basel Keyword: ddc:610; Medizin URL: https://doi.org/10.1159/000322370 https://epub.ub.uni-muenchen.de/16909/1/10_1159_000322370.pdf http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-16909-3 https://epub.ub.uni-muenchen.de/16909/ BASE Hide details 2 Cerebrospinal Fluid Tau, p-Tau 181 and Amyloid-β38/40/42 in Frontotemporal Dementias and Primary Progressive Aphasias Bibl, Mirko; Mollenhauer, Brit; Lewczuk, Piotr. - 2011 BASE Show details 3 CSF amyloid-ß-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia Bibl, Mirko; Mollenhauer, Brit; Esselmann, Hermann... In: Brain. - Oxford : Oxford Univ. Press 129 (2006) 5, 1177-1187 BLLDB Show details

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