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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 20 of 20 1 Cortical microstructure in primary progressive aphasia: a multicenter study. Illán-Gala, Ignacio; Montal, Victor; Borrego-Écija, Sergi; Mandelli, Maria Luisa; Falgàs, Neus; Welch, Ariane E; Pegueroles, Jordi; Santos-Santos, Miguel; Bejanin, Alexandre; Alcolea, Daniel; Dols-Icardo, Oriol; Belbin, Olivia; Sánchez-Saudinós, Mª Belén; Bargalló, Nuria; González-Ortiz, Sofía; Lladó, Albert; Blesa, Rafael; Dickerson, Bradford C; Rosen, Howard J; Miller, Bruce L; Lleó, Alberto; Gorno-Tempini, Maria Luisa; Sánchez-Valle, Raquel; Fortea, Juan In: Alzheimer's research & therapy, vol 14, iss 1 (2022) Abstract: BackgroundCortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA).MethodsIn this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach.ResultsThe comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity.ConclusionsCortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA. Keyword: 2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aging; Alzheimer's disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer’s disease; Aphasia; Biomedical Imaging; Brain Disorders; Case-Control Studies; Clinical Research; Dementia; Diffusion; Diffusion Magnetic Resonance Imaging; Frontotemporal Dementia (FTD); Frontotemporal lobar degeneration; Humans; Magnetic resonance; Magnetic Resonance Imaging; Medical and Health Sciences; Neurodegenerative; Neurological; Neurosciences; Primary Progressive; Primary progressive aphasia; Rare Diseases URL: https://escholarship.org/uc/item/4td346vg BASE Hide details 2 Uniform data set language measures for bvFTD and PPA diagnosis and monitoring. Staffaroni, Adam M; Weintraub, Sandra; Rascovsky, Katya... In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021) BASE Show details 3 Uniform data set language measures for bvFTD and PPA diagnosis and monitoring. Staffaroni, Adam M; Weintraub, Sandra; Rascovsky, Katya... In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021) BASE Show details 4 Comparing two facets of emotion perception across multiple neurodegenerative diseases. Brown, Casey L; Hua, Alice Y; De Coster, Lize... In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020) BASE Show details 5 Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages. Shdo, Suzanne M; Ranasinghe, Kamalini G; Sturm, Virginia E. - : eScholarship, University of California, 2020 BASE Show details 6 Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium. Miyagawa, Toji; Brushaber, Danielle; Syrjanen, Jeremy... In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020) BASE Show details 7 Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages. Shdo, Suzanne M; Ranasinghe, Kamalini G; Sturm, Virginia E. - : eScholarship, University of California, 2020 BASE Show details 8 Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium. Miyagawa, Toji; Brushaber, Danielle; Syrjanen, Jeremy... In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020) BASE Show details 9 Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers. Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019 BASE Show details 10 Factors that predict diagnostic stability in neurodegenerative dementia. Perry, David C; Datta, Samir; Miller, Zachary A... In: Journal of neurology, vol 266, iss 8 (2019) BASE Show details 11 Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers. Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019 BASE Show details 12 Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia. Miller, Zachary A; Spina, Salvatore; Pakvasa, Mikhail... In: Brain communications, vol 1, iss 1 (2019) BASE Show details 13 Physiological, behavioral and subjective sadness reactivity in frontotemporal dementia subtypes. Hua, Alice Y; Chen, Kuan-Hua; Brown, Casey L... In: Social cognitive and affective neuroscience, vol 14, iss 12 (2019) BASE Show details 14 Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory. Ljubenkov, Peter A; Staffaroni, Adam M; Rojas, Julio C... In: Annals of clinical and translational neurology, vol 5, iss 10 (2018) BASE Show details 15 Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia. Santos-Santos, Miguel A; Rabinovici, Gil D; Iaccarino, Leonardo... In: JAMA neurology, vol 75, iss 3 (2018) BASE Show details 16 Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease. Elahi, Fanny M; Marx, Gabe; Cobigo, Yann. - : eScholarship, University of California, 2017 BASE Show details 17 Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease. Elahi, Fanny M; Marx, Gabe; Cobigo, Yann. - : eScholarship, University of California, 2017 BASE Show details 18 Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture. Miller, Zachary A; Sturm, Virginia E; Camsari, Gamze Balci... In: Neurology(R) neuroimmunology & neuroinflammation, vol 3, iss 6 (2016) BASE Show details 19 Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease. Ossenkoppele, Rik; Cohn-Sheehy, Brendan I; La Joie, Renaud... In: Human brain mapping, vol 36, iss 11 (2015) BASE Show details 20 Neural substrates of socioemotional self-awareness in neurodegenerative disease. Sollberger, Marc; Rosen, Howard J; Shany-Ur, Tal... In: Brain and behavior, vol 4, iss 2 (2014) BASE Show details

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