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Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates ...
Abstract: Objective: Behavioral variant frontotemporal dementia (bvFTD), is commonly considered the cognitive presentation of the frontotemporal dementia-motor neuron disease (FTD-MND) spectrum disorder. We evaluated the prevalence of primary progressive aphasia in a series of pathologically confirmed cases of FTD-MND spectrum. Methods: Pathologically confirmed cases of frontotemporal lobar degeneration-motor neuron disease (FTLD-MND) were obtained from the UCSF brain bank. Cases were analyzed for presence of language impairment via retrospective chart review of research visits that include neurologic exam, in-depth cognitive testing and magnetic resonance imaging (MRI) imaging. Forty one cases were included. Thirty two were diagnosed with FTD-MND, while nine cases were diagnosed as MND-only from clinical evaluation. Results: Ten FTLD-MND cases (31%) presented with prominent or isolated language involvement consistent with a diagnosis of primary progressive aphasia (PPA), which we called progressive aphasia with motor ...
Keyword: FOS Sociology; Medicine; Neuroscience; Sociology
URL: https://dx.doi.org/10.6084/m9.figshare.7615766
https://tandf.figshare.com/articles/Primary_progressive_aphasia_and_the_FTD-MND_spectrum_disorders_clinical_pathological_and_neuroimaging_correlates/7615766
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2
Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates ...
Vinceti, Giulia; Olney, Nicholas; Mandelli, Maria Luisa. - : Taylor & Francis, 2020
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3
Task-Free Functional Language Networks: Reproducibility and Clinical Application
In: J Neurosci (2020)
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4
Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates ...
Vinceti, Giulia; Olney, Nicholas; Mandelli, Maria Luisa. - : Taylor & Francis, 2019
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5
Differential intrinsic functional connectivity changes in semantic variant primary progressive aphasia
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6
Alzheimer’s disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation
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7
Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers
Lee, Suzee E.; Sias, Ana C.; Kosik, Eena L.. - : Elsevier, 2019
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8
Patient-Tailored, Connectivity-Based Forecasts of Spreading Brain Atrophy
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9
Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy
Miller, Zachary A.; Rosenberg, Lynne; Santos-Santos, Miguel A.. - : American Medical Association, 2018
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10
Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia
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11
Rates Of Amyloid Imaging Positivity In Patients With Primary Progressive Aphasia
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12
Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia
Collins, Jessica A.; Montal, Victor; Hochberg, Daisy. - : Oxford University Press, 2017
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13
Healthy brain connectivity predicts atrophy progression in non-fluent variant of primary progressive aphasia
Mandelli, Maria Luisa; Vilaplana, Eduard; Brown, Jesse A.. - : Oxford University Press, 2016
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14
Two insular regions are differentially involved in behavioral variant FTD and nonfluent/agrammatic variant PPA
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15
Loss of functional connectivity is greater outside the default mode network in non-familial early-onset Alzheimer’s disease variants
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16
Atrophy Patterns in Early Clinical Stages Across Distinct Phenotypes of Alzheimer’s Disease
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17
In vivo signatures of nonfluent/agrammatic primary progressive aphasia caused by FTLD pathology
Caso, Francesca; Mandelli, Maria Luisa; Henry, Maya. - : Lippincott Williams & Wilkins, 2014
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18
Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease
Lehmann, Manja; Ghosh, Pia M.; Madison, Cindee. - : Oxford University Press, 2013
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19
Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease
Lehmann, Manja; Ghosh, Pia M.; Madison, Cindee. - : Oxford University Press, 2013
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20
Anterior temporal lobe degeneration produces widespread network-driven dysfunction
Guo, Christine C.; Gorno-Tempini, Maria Luisa; Gesierich, Benno. - : Oxford University Press, 2013
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