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1
Dynamic functional brain network connectivity during pseudoword processing relates to children’s reading skill
Abstract: Learning to read requires children to link print (orthography) with its corresponding speech sounds (phonology). Yet, most EEG studies of reading development focus on emerging functional specialization (e.g., developing increasingly refined orthographic representations), rather than directly measuring the functional connectivity that links orthography and phonology in real time. In this proof-of-concept study we relate children's reading skill to both orthographic specialization for print (via the N170, also called the N1, event related potential, ERP) and orthographic-phonological integration (via dynamic/event-related EEG phase synchronization – an index of functional brain network connectivity). Typically developing English speaking children (n = 24; 4–14 years) and control adults (n = 20; 18–35 years) viewed pseudowords, consonants and unfamiliar false fonts during a 1-back memory task while 64-channel EEG was recorded. Orthographic specialization (larger N170 for pseudowords vs. false fonts) became more left-lateralized with age, but not with reading skill. Conversely, children's reading skill correlated with functional brain network connectivity during pseudoword processing that requires orthography-phonology linking. This was seen during two periods of simultaneous low frequency synchronization/high frequency desynchronization of posterior-occipital brain network activity. Specifically, in stronger readers, left posterior-occipital activity showed more delta (1–3Hz) synchronization around 300–500 ms (simultaneous with gamma 30–80 Hz desynchronization) and more gamma desynchronization around 600–1000 ms (simultaneous with theta 3–7Hz synchronization) during pseudoword vs. false font processing. These effects were significant even when controlling for age (moderate – large effect sizes). Dynamic functional brain network connectivity measures the brain's real-time sound-print linking. It may offer an under-explored, yet sensitive, index of the neural plasticity associated with reading development. Reading requires us to link visual print with speech sound processing. Yet, most EEG reading research explores functional specialization not integration. While children's age relates to ERPs (N170) associated with print specialization. Children's reading skill relates to real-time functional brain network connectivity. EEG phase synchrony = sensitive index of functional integration during reading.
Keyword: Adolescent; Adult; Brain mapping; Brain research; Brain-diagnostic imaging; Child; Children's hospitals; EEG phase Synchrony (phase lag index); Electroencephalography; Evoked potentials; Functional brain network connectivity; Humans; N170; Neurosciences; Orthography; Phonetics; Phonology; preschool; Reading; Reading development; Young Adult
URL: http://hdl.handle.net/10464/15658
https://doi.org/10.1016/j.neuropsychologia.2022.108181
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2
Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation.
In: Journal of neurodevelopmental disorders, vol 14, iss 1 (2022)
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3
A Therapeutic Relational Agent for Reducing Problematic Substance Use (Woebot): Development and Usability Study.
In: Journal of medical Internet research, vol 23, iss 3 (2021)
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4
A Bayesian optimization approach for rapidly mapping residual network function in stroke. ...
Lorenz, Romy; Johal, Michelle; Dick, Frederic. - : Apollo - University of Cambridge Repository, 2021
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5
Age-related differences in the neural bases of phonological and semantic processes in the context of task-irrelevant information.
Truong, Trong-Kha; Johnson, Micah A; Madden, David J. - : Springer Science and Business Media LLC, 2021
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6
Age-related differences in the neural bases of phonological and semantic processes.
Burke, Deborah M; Diaz, Michele T; Madden, David J. - : MIT Press - Journals, 2021
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7
Age-related differences in resolving semantic and phonological competition during receptive language tasks.
Madden, David J; Johnson, Micah A; Zhuang, Jie. - : Elsevier BV, 2021
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8
Sustained neural rhythms reveal endogenous oscillations supporting speech perception. ...
Van Bree, Sander; Sohoglu, Ediz; Davis, Matt. - : Apollo - University of Cambridge Repository, 2021
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9
Language networks in aphasia and health: A 1000 participant activation likelihood estimation meta-analysis. ...
Stefaniak, James D; Alyahya, Reem SW; Lambon Ralph, Matthew. - : Apollo - University of Cambridge Repository, 2021
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10
A Bayesian optimization approach for rapidly mapping residual network function in stroke.
Lorenz, Romy; Johal, Michelle; Dick, Frederic. - : Oxford University Press (OUP), 2021. : Brain, 2021
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11
Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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12
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
Chapleau, Marianne; Bedetti, Christophe; Devenyi, Gabriel A. - : eScholarship, University of California, 2020
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13
Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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14
A multi-level developmental approach to exploring individual differences in Down syndrome: genes, brain, behaviour, and environment. ...
Thomas, Michael SC; Ojinaga Alfageme, Olatz; D'Souza, Hana. - : Apollo - University of Cambridge Repository, 2020
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15
Rapid computations of spectrotemporal prediction error support perception of degraded speech. ...
Sohoglu, Ediz; Davis, Matt. - : Apollo - University of Cambridge Repository, 2020
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16
The Neural Time Course of Semantic Ambiguity Resolution in Speech Comprehension. ...
MacGregor, Lucy; Rodd, Jennifer M; Gilbert, Becky. - : Apollo - University of Cambridge Repository, 2020
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17
A multi-level developmental approach to exploring individual differences in Down syndrome: genes, brain, behaviour, and environment.
Thomas, Michael SC; Ojinaga Alfageme, Olatz; D'Souza, Hana. - : Research in developmental disabilities, 2020
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18
Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019
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19
Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019
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20
Discourse Process Training and Attention Process Training 2 in Adults with Traumatic Brain Injury
Henderson, Amy. - : East Carolina University, 2019
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