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Health comorbidities and cognitive abilities across the lifespan in Down syndrome. ...
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Startin, Carla M; D'Souza, Hana; Ball, George; Hamburg, Sarah; Hithersay, Rosalyn; Hughes, Kate MO; Massand, Esha; Karmiloff-Smith, Annette; Thomas, Michael SC; LonDownS Consortium; Strydom, Andre. - : Apollo - University of Cambridge Repository, 2020
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Abstract:
BACKGROUND: Down syndrome (DS) is associated with variable intellectual disability and multiple health and psychiatric comorbidities. The impact of such comorbidities on cognitive outcomes is unknown. We aimed to describe patterns of physical health and psychiatric comorbidity prevalence, and receptive language ability, in DS across the lifespan, and determine relationships with cognitive outcomes. METHODS: Detailed medical histories were collected and cognitive abilities measured using standardised tests for 602 individuals with DS from England and Wales (age range 3 months to 73 years). Differences in prevalence rates between age groups and between males and females were determined using chi-squared or Fisher's exact tests. In adults, rates for psychiatric comorbidities were compared to expected population rates using standardised morbidity ratios (SMRs). Adapted ANCOVA functions were constructed to explore age and sex associations with receptive language ability across the lifespan, and regression ...
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Keyword:
Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cognition; Comorbidity; Down Syndrome; Female; Humans; Infant; Language Development Disorders; LonDownS Consortium; Longevity; Male; Mental Disorders; Middle Aged; Sex Characteristics; United Kingdom; Young Adult
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URL: https://www.repository.cam.ac.uk/handle/1810/311092
https://dx.doi.org/10.17863/cam.58181
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What Do North American Babies Hear? A large-scale cross-corpus analysis.
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Health comorbidities and cognitive abilities across the lifespan in Down syndrome.
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