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1
Dynamic functional brain network connectivity during pseudoword processing relates to children’s reading skill
Abstract: Learning to read requires children to link print (orthography) with its corresponding speech sounds (phonology). Yet, most EEG studies of reading development focus on emerging functional specialization (e.g., developing increasingly refined orthographic representations), rather than directly measuring the functional connectivity that links orthography and phonology in real time. In this proof-of-concept study we relate children's reading skill to both orthographic specialization for print (via the N170, also called the N1, event related potential, ERP) and orthographic-phonological integration (via dynamic/event-related EEG phase synchronization – an index of functional brain network connectivity). Typically developing English speaking children (n = 24; 4–14 years) and control adults (n = 20; 18–35 years) viewed pseudowords, consonants and unfamiliar false fonts during a 1-back memory task while 64-channel EEG was recorded. Orthographic specialization (larger N170 for pseudowords vs. false fonts) became more left-lateralized with age, but not with reading skill. Conversely, children's reading skill correlated with functional brain network connectivity during pseudoword processing that requires orthography-phonology linking. This was seen during two periods of simultaneous low frequency synchronization/high frequency desynchronization of posterior-occipital brain network activity. Specifically, in stronger readers, left posterior-occipital activity showed more delta (1–3Hz) synchronization around 300–500 ms (simultaneous with gamma 30–80 Hz desynchronization) and more gamma desynchronization around 600–1000 ms (simultaneous with theta 3–7Hz synchronization) during pseudoword vs. false font processing. These effects were significant even when controlling for age (moderate – large effect sizes). Dynamic functional brain network connectivity measures the brain's real-time sound-print linking. It may offer an under-explored, yet sensitive, index of the neural plasticity associated with reading development. Reading requires us to link visual print with speech sound processing. Yet, most EEG reading research explores functional specialization not integration. While children's age relates to ERPs (N170) associated with print specialization. Children's reading skill relates to real-time functional brain network connectivity. EEG phase synchrony = sensitive index of functional integration during reading.
Keyword: Adolescent; Adult; Brain mapping; Brain research; Brain-diagnostic imaging; Child; Children's hospitals; EEG phase Synchrony (phase lag index); Electroencephalography; Evoked potentials; Functional brain network connectivity; Humans; N170; Neurosciences; Orthography; Phonetics; Phonology; preschool; Reading; Reading development; Young Adult
URL: http://hdl.handle.net/10464/15658
https://doi.org/10.1016/j.neuropsychologia.2022.108181
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2
Development of a standard of care for patients with valosin-containing protein associated multisystem proteinopathy.
In: Orphanet journal of rare diseases, vol 17, iss 1 (2022)
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3
Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation.
In: Journal of neurodevelopmental disorders, vol 14, iss 1 (2022)
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4
Cortical microstructure in primary progressive aphasia: a multicenter study.
In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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5
Providing a parent-administered outcome measure in a bilingual family of a father and a mother of two adolescents with ASD: brief report.
In: Developmental neurorehabilitation, vol 25, iss 2 (2022)
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6
Open access dataset of task-free hemodynamic activity in 4-month-old infants during sleep using fNIRS. ...
Blanco, Borja; Molnar, Monika; Carreiras, Manuel. - : Apollo - University of Cambridge Repository, 2022
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7
Human cortical encoding of pitch in tonal and non-tonal languages.
In: Nature communications, vol 12, iss 1 (2021)
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8
Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
Yang, Winson FZ; Toller, Gianina; Shdo, Suzanne. - : eScholarship, University of California, 2021
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9
Neural dynamics of semantic categorization in semantic variant of primary progressive aphasia.
Borghesani, V; Dale, CL; Lukic, S. - : eScholarship, University of California, 2021
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10
Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
Yang, Winson FZ; Toller, Gianina; Shdo, Suzanne. - : eScholarship, University of California, 2021
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11
A Therapeutic Relational Agent for Reducing Problematic Substance Use (Woebot): Development and Usability Study.
In: Journal of medical Internet research, vol 23, iss 3 (2021)
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12
A Bayesian optimization approach for rapidly mapping residual network function in stroke. ...
Lorenz, Romy; Johal, Michelle; Dick, Frederic. - : Apollo - University of Cambridge Repository, 2021
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13
Age-related differences in the neural bases of phonological and semantic processes in the context of task-irrelevant information.
Truong, Trong-Kha; Johnson, Micah A; Madden, David J. - : Springer Science and Business Media LLC, 2021
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14
Age-related differences in the neural bases of phonological and semantic processes.
Burke, Deborah M; Diaz, Michele T; Madden, David J. - : MIT Press - Journals, 2021
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15
Age-related differences in resolving semantic and phonological competition during receptive language tasks.
Madden, David J; Johnson, Micah A; Zhuang, Jie. - : Elsevier BV, 2021
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16
Sustained neural rhythms reveal endogenous oscillations supporting speech perception. ...
Van Bree, Sander; Sohoglu, Ediz; Davis, Matt. - : Apollo - University of Cambridge Repository, 2021
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17
Language networks in aphasia and health: A 1000 participant activation likelihood estimation meta-analysis. ...
Stefaniak, James D; Alyahya, Reem SW; Lambon Ralph, Matthew. - : Apollo - University of Cambridge Repository, 2021
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18
A Bayesian optimization approach for rapidly mapping residual network function in stroke.
Lorenz, Romy; Johal, Michelle; Dick, Frederic. - : Oxford University Press (OUP), 2021. : Brain, 2021
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19
Expressive language development in adolescents with Down syndrome and fragile X syndrome: change over time and the role of family-related factors.
In: Journal of neurodevelopmental disorders, vol 12, iss 1 (2020)
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20
New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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