| 1 |
Inter- and intrahemispheric connectivity differences when reading Japanese Kanji and Hiragana.
|
|
|
|
In: Cereb Cortex , 24 (6) pp. 1601-1608. (2014) (2014)
|
|
BASE
|
|
Show details
|
|
|
| 2 |
The importance of premotor cortex for supporting speech production after left capsular-putaminal damage.
|
|
|
|
In: J Neurosci , 34 (43) 14338 - 14348. (2014) (2014)
|
|
Abstract:
The left putamen is known to be important for speech production, but some patients with left putamen damage can produce speech remarkably well. We investigated the neural mechanisms that support this recovery by using a combination of techniques to identify the neural regions and pathways that compensate for loss of the left putamen during speech production. First, we used fMRI to identify the brain regions that were activated during reading aloud and picture naming in a patient with left putamen damage. This revealed that the patient had abnormally high activity in the left premotor cortex. Second, we used dynamic causal modeling of the patient's fMRI data to understand how this premotor activity influenced other speech production regions and whether the same neural pathway was used by our 24 neurologically normal control subjects. Third, we validated the compensatory relationship between putamen and premotor cortex by showing, in the control subjects, that lower connectivity through the putamen increased connectivity through premotor cortex. Finally, in a lesion-deficit analysis, we demonstrate the explanatory power of our fMRI results in new patients who had damage to the left putamen, left premotor cortex, or both. Those with damage to both had worse reading and naming scores. The results of our four-pronged approach therefore have clinical implications for predicting which patients are more or less likely to recover their speech after left putaminal damage.
|
|
Keyword:
Adult; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Motor Cortex; Premotor cortex; putamen; reading words; recovery pathways; Speech; subcortical stroke; Young Adult
|
|
URL: http://discovery.ucl.ac.uk/1454205/
|
|
BASE
|
|
Hide details
|
|
|
| 3 |
Perturbation of the left inferior frontal gyrus triggers adaptive plasticity in the right homologous area during speech production.
|
|
|
|
In: Proc Natl Acad Sci U S A , 110 (41) 16402 - 16407. (2013) (2013)
|
|
BASE
|
|
Show details
|
|
|
| 4 |
Reading without the left ventral occipito-temporal cortex.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2012)
|
|
BASE
|
|
Show details
|
|
|
| 5 |
Where, when and why brain activation differs for bilinguals and monolinguals during picture naming and reading aloud.
|
|
|
|
In: Cereb Cortex , 22 (4) 892 - 902. (2012) (2012)
|
|
BASE
|
|
Show details
|
|
|
| 6 |
Where, when and why brain activation differs for bilinguals and monolinguals during picture naming and reading aloud.
|
|
|
|
In: Cereb Cortex , 22 (4) 892 - 902. (2012) (2012)
|
|
BASE
|
|
Show details
|
|
|
| 7 |
Auditory short-term memory capacity correlates with gray matter density in the left posterior STS in cognitively normal and dyslexic adults.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2011)
|
|
BASE
|
|
Show details
|
|
|
| 8 |
Semantic relevance explains category effects in medial fusiform gyri.
|
|
|
|
In: Neuroimage , 30 (3) pp. 992-1002. (2006) (2006)
|
|
BASE
|
|
Show details
|
|
|
| 9 |
Reading and reading disturbance.
|
|
|
|
In: Curr Opin Neurobiol , 15 (2) pp. 231-238. (2005) (2005)
|
|
BASE
|
|
Show details
|
|
|
| 10 |
Meta-analyses of object naming: effect of baseline.
|
|
|
|
In: Hum Brain Mapp , 25 (1) pp. 70-82. (2005) (2005)
|
|
BASE
|
|
Show details
|
|
|
| 11 |
The anatomy and time course of semantic priming investigated by fMRI and ERPs.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; CrossRef (2003)
|
|
BASE
|
|
Show details
|
|
|
| 12 |
Neuroimaging studies of word and pseudoword reading: consistencies, inconsistencies, and limitations.
|
|
|
|
In: J Cogn Neurosci , 15 (2) pp. 260-271. (2003) (2003)
|
|
BASE
|
|
Show details
|
|
|
| 13 |
The anatomy and time course of semantic priming investigated by fMRI and ERPs.
|
|
|
|
In: Neuropsychologia , 41 (5) pp. 550-564. (2003) (2003)
|
|
BASE
|
|
Show details
|
|
|
| 14 |
Functional imaging of the semantic system: retrieval of sensory-experienced and verbally learned knowledge.
|
|
|
|
In: Brain Lang , 84 (1) pp. 120-133. (2003) (2003)
|
|
BASE
|
|
Show details
|
|
|
| 15 |
The constraints functional neuroimaging places on classical models of auditory word processing.
|
|
|
|
In: J Cogn Neurosci , 13 (6) pp. 754-765. (2001) (2001)
|
|
BASE
|
|
Show details
|
|
|
| 16 |
Cross-modal plasticity underpins language recovery after cochlear implantation.
|
|
|
|
In: Neuron , 30 (3) pp. 657-663. (2001) (2001)
|
|
BASE
|
|
Show details
|
|
|
| 17 |
Functional-imaging studies of the 19th Century neurological model of language.
|
|
|
|
In: Rev Neurol (Paris) , 157 (8-9 Pt 1) pp. 833-836. (2001) (2001)
|
|
BASE
|
|
Show details
|
|
|
| 18 |
The anatomy of language: contributions from functional neuroimaging.
|
|
|
|
In: J Anat , 197 Pt pp. 335-359. (2000) (2000)
|
|
BASE
|
|
Show details
|
|
|
| 19 |
Disrupted temporal lobe connections in semantic dementia.
|
|
|
|
In: Brain , 122 ( pp. 61-73. (1999) (1999)
|
|
BASE
|
|
Show details
|
|
|
| 20 |
Three distinct ventral occipitotemporal regions for reading and object naming.
|
|
|
|
In: Neuroimage , 10 (2) pp. 181-192. (1999) (1999)
|
|
BASE
|
|
Show details
|
|
|
|
|
