• Refine your search:
  • 
    Keyword:
    
    • Original Articles (3)
  • 
    Creator / Publisher:
    
    • Bishop, D V M (3)
    • Ang, Q W (1)
    • Barry, J G (1)
    • Fisher, S E (1)
    • Hayiou-Thomas, M E (1)
    • Pennell, C E (1)
    • Whitehouse, A J O (1)
    • Yasin, I (1)
  • 
    Year
  • 
    Medium
  • 
    Type
  • 
    BLLDB-Access

Search in the Catalogues and Directories

All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 3 of 3 1 CNTNAP2 variants affect early language development in the general population Fisher, S E; Whitehouse, A J O; Bishop, D V M; Pennell, C E; Ang, Q W. - : Blackwell Publishing Ltd, 2011 Abstract: Early language development is known to be under genetic influence, but the genes affecting normal variation in the general population remain largely elusive. Recent studies of disorder reported that variants of the CNTNAP2 gene are associated both with language deficits in specific language impairment (SLI) and with language delays in autism. We tested the hypothesis that these CNTNAP2 variants affect communicative behavior, measured at 2 years of age in a large epidemiological sample, the Western Australian Pregnancy Cohort (Raine) Study. Singlepoint analyses of 1149 children (606 males and 543 females) revealed patterns of association which were strikingly reminiscent of those observed in previous investigations of impaired language, centered on the same genetic markers and with a consistent direction of effect (rs2710102, P = 0.0239; rs759178, P = 0.0248). On the basis of these findings, we performed analyses of four-marker haplotypes of rs2710102–rs759178–rs17236239–rs2538976 and identified significant association (haplotype TTAA, P = 0.049; haplotype GCAG, P = .0014). Our study suggests that common variants in the exon 13–15 region of CNTNAP2 influence early language acquisition, as assessed at age 2, in the general population. We propose that these CNTNAP2 variants increase susceptibility to SLI or autism when they occur together with other risk factors. Keyword: Original Articles URL: http://www.ncbi.nlm.nih.gov/pubmed/21310003 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130139 https://doi.org/10.1111/j.1601-183X.2011.00684.x BASE Hide details 2 Heritability of specific language impairment depends on diagnostic criteria Bishop, D V M; Hayiou-Thomas, M E. - : Blackwell Publishing Ltd, 2008 BASE Show details 3 Heritable risk factors associated with language impairments Barry, J G; Yasin, I; Bishop, D V M. - : Blackwell Publishing Ltd, 2007 BASE Show details

Mobile view All Catalogues UB Frankfurt Linguistik 0 IDS Mannheim 0 OLC Linguistik 0 UB Frankfurt Retrokatalog 0 DNB Subject Category Language 0 Institut für Empirische Sprachwissenschaft 0 Leibniz-Centre General Linguistics (ZAS) 0 Bibliographies BLLDB 0 BDSL 0 IDS Bibliografie zur deutschen Grammatik 0 IDS Bibliografie zur Gesprächsforschung 0 IDS Konnektoren im Deutschen 0 IDS Präpositionen im Deutschen 0 IDS OBELEX meta 0 MPI-SHH Linguistics Collection 0 MPI for Psycholinguistics 0 Linked Open Data catalogues Annohub 0 Online resources Link directory 0 Journal directory 0 Database directory 0 Dictionary directory 0 Open access documents BASE 3 Linguistik-Repository 0 IDS Publikationsserver 0 Online dissertations 0 Language Description Heritage 0