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The puzzling nuanced status of who free relative clauses in English: a follow-up to Patterson and Caponigro (2015)
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In: ENGLISH LANGUAGE & LINGUISTICS, vol 26, iss 1 (2022)
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Preview benefits and preview costs during reading: Exploring the interplay between display change awareness and parafoveal visual degradation (VISDEG2 project)) ...
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Spectral Degradation Influences Phonological Memory in Typically Hearing Adults
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In: Communication Disorders Faculty Publications (2021)
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SOCIO-CULTURAL TRANSFORMATION IN POST-SOVIET UKRAINE ; СОЦИОКУЛЬТУРНАЯ ТРАНСФОРМАЦИЯ В ПОСТСОВЕТСКОЙ УКРАИНЕ ; СОЦІОКУЛЬТУРНА ТРАНСФОРМАЦІЯ В ПОСТРАДЯНСЬКІЙ УКРАЇНІ
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In: Skhid; No. 1(2) (2021): PHILOSOPHICAL SCIENCES; 43-51 ; Схид; № 1(2) (2021): ФИЛОСОФСКИЕ НАУКИ; 43-51 ; Схід; № 1(2) (2021): ФІЛОСОФСЬКІ НАУКИ; 43-51 ; 2411-3093 ; 1728-9343 ; 10.21847/1728-9343.2021.1(2) (2021)
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Mapping of soil degradation and vulnerability in the Noun Syed watershed by water erosion: what impacts of climate change approach by remote sensing and GIS ...
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AOURAGH, Mbark. - : Environmental and Water Sciences, public Health and Territorial Intelligence Journal, 2020
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A Review on Alkali-Silica Reaction Evolution in Recycled Aggregate Concrete
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In: Materials ; Volume 13 ; Issue 11 (2020)
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High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation
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In: J Biol Chem (2019)
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Abstract:
Repeat-associated non-AUG (RAN) translation is a noncanonical translation initiation event that occurs at nucleotide-repeat expansion mutations that are associated with several neurodegenerative diseases, including fragile X–associated tremor ataxia syndrome (FXTAS), ALS, and frontotemporal dementia (FTD). Translation of expanded repeats produces toxic proteins that accumulate in human brains and contribute to disease pathogenesis. Consequently, RAN translation constitutes a potentially important therapeutic target for managing multiple neurodegenerative disorders. Here, we adapted a previously developed RAN translation assay to a high-throughput format to screen 3,253 bioactive compounds for inhibition of RAN translation of expanded CGG repeats associated with FXTAS. We identified five diverse small molecules that dose-dependently inhibited CGG RAN translation, while relatively sparing canonical translation. All five compounds also inhibited RAN translation of expanded GGGGCC repeats associated with ALS and FTD. Using CD and native gel analyses, we found evidence that three of these compounds, BIX01294, CP-31398, and propidium iodide, bind directly to the repeat RNAs. These findings provide proof-of-principle supporting the development of selective small-molecule RAN translation inhibitors that act across multiple disease-causing repeats.
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Keyword:
Protein Synthesis and Degradation
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901296/ https://doi.org/10.1074/jbc.RA119.009951 http://www.ncbi.nlm.nih.gov/pubmed/31649034
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Polyadenylate-binding protein–interacting proteins PAIP1 and PAIP2 affect translation termination
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In: J Biol Chem (2019)
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Transparent free relatives with "who": Support for a unified analysis
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In: Proceedings of the Linguistic Society of America; Vol 4 (2019): Proceedings of the Linguistic Society of America; 40:1–6 ; 2473-8689 (2019)
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The Interaction of Temporal and Spectral Acoustic Information with Word Predictability on Speech Intelligibility
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In: Communication Studies Theses, Dissertations, and Student Research (2017)
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Post-Translational Nuclear Protein Modification and High Vitamin-D Receptor Levels in Genetic Hypercalciuric Stone-Forming Rats
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In: Journal of Health Disparities Research and Practice (2016)
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Discriminability and Perceptual Saliency of Temporal and Spectral Cues for Final Fricative Consonant Voicing in Simulated Cochlear-Implant and Bimodal Hearing
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In: Communication Sciences and Disorders Faculty Publications (2016)
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Photocatalytic Degradation of the Azo Dye Acid Red 14 in Nanosized TiO2 Suspension under Simulated Solar Light
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In: Research outputs 2014 to 2021 (2015)
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L'émergence de formes nouvelles dans le parler ncàm (bassar) moderne
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In: Regards scientifiques croisés sur le changement global et le développement - Langue, environnement, culture : Actes du Colloque international de Ouagadougou (8-10 mars 2012) ; Langue, environnement, culture : pluridisciplinarité et développement ; https://hal.archives-ouvertes.fr/hal-00939892 ; Gwenaëlle FABRE, Anne FOURNIER, Lamine SANOGO. Regards scientifiques croisés sur le changement global et le développement - Langue, environnement, culture : Actes du Colloque international de Ouagadougou (8-10 mars 2012), Sciencesconf.org, pp.93-106, 2014 (2014)
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