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Details of Genomewide Association Results, Protocol, Statistical Analysis, and Additional References (Harlaar et al., 2014) ...
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Details of Genomewide Association Results, Protocol, Statistical Analysis, and Additional References (Harlaar et al., 2014) ...
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Harlaar, Nicole; L. Meaburn, Emma; E. Hayiou-Thomas, Marianna; S. P. Davis, Oliver; Docherty, Sophia; B. Hanscombe, Ken; M. A. Haworth, Claire; S. Price, Thomas; Trzaskowski, Maciej; S. Dale, Philip; Plomin, Robert. - : ASHA journals, 2014
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Abstract:
Purpose Researchers have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. In the current study, the authors attempted to identify some of the genes responsible for the heritability of receptive language ability using a genome-wide association approach. Method The authors administered 4 Internet-based measures of receptive language (vocabulary, semantics, syntax, and pragmatics) to a sample of 2,329 twelve-year-olds for whom DNA and genome-wide genotyping were available. Nearly 700,000 single-nucleotide polymorphisms (SNPs) and 1 million imputed SNPs were included in a genome-wide association analysis of receptive language composite scores. Results No SNP associations met the demanding criterion of genome-wide significance that corrects for multiple testing across the genome ( p < 5 × 10−8). The strongest SNP association did not replicate in an additional sample of 2,639 twelve-year-olds. Conclusions These results indicate that ...
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Keyword:
170204 Linguistic Processes incl. Speech Production and Comprehension; FOS Psychology
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URL: https://dx.doi.org/10.23641/asha.6170411.v1
https://asha.figshare.com/articles/dataset/Details_of_Genomewide_Association_Results_Protocol_Statistical_Analysis_and_Additional_References_Harlaar_et_al_2014_/6170411/1
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