1 |
METHODS OF EXPRESSING EVALUATION IN ENGLISH LANGUAGE PAREMIAS ...
|
|
|
|
BASE
|
|
Show details
|
|
2 |
The relationship between developmental language disorder and dyslexia in European Portuguese school-aged children
|
|
|
|
BASE
|
|
Show details
|
|
3 |
Adults with a history of recreational cannabis use have altered speech production
|
|
|
|
BASE
|
|
Show details
|
|
4 |
Tapping into non-English-language science for the conservation of global biodiversity
|
|
|
|
BASE
|
|
Show details
|
|
5 |
The trans-ancestral genomic architecture of glycemic traits.
|
|
|
|
In: Nature genetics, vol. 53, no. 6, pp. 840-860 (2021)
|
|
BASE
|
|
Show details
|
|
6 |
Corpus Analysis of Engagement Discourse Strategies in Academic Presentations
|
|
|
|
In: World Languages Faculty Publications and Presentations (2020)
|
|
BASE
|
|
Show details
|
|
7 |
Comparison of the Perspectives of Medical Students and Residents on the Surgery Learning Environment
|
|
|
|
In: J Surg Res (2020)
|
|
BASE
|
|
Show details
|
|
8 |
Mimicry of canonical translation elongation underlies alanine tail synthesis in RQC
|
|
|
|
In: Mol Cell (2020)
|
|
Abstract:
Aborted translation produces large ribosomal subunits obstructed with tRNA-linked nascent-chains, which are substrates of Ribosome-associated Quality Control (RQC). Bacterial RqcH, a widely-conserved RQC factor, senses the obstruction and recruits tRNA(Ala(UGC)) to modify nascent-chain C-termini with a polyalanine-degron. However, how RqcH and eukaryotic homologs, despite their relatively simple architecture, synthesize such C-terminal tails in the absence of a small ribosomal subunit and mRNA has remained unknown. Here we present cryo-EM structures of Bacillus subtilis RQC complexes representing different Ala-tail synthesis steps. The structures explain how tRNA(Ala) is selected via anticodon reading during recruitment to the A-site, and uncover striking hinge-like movements in RqcH leading tRNA(Ala) into a hybrid A/P-state associated with peptidyl-transfer. Finally, we provide structural, biochemical and molecular genetic evidence identifying the Hsp15 homolog as a novel RQC component that completes the cycle by stabilizing the P-site tRNA conformation. Ala-tailing thus follows mechanistic principles surprisingly similar to canonical translation elongation.
|
|
Keyword:
Article
|
|
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796892/ http://www.ncbi.nlm.nih.gov/pubmed/33259811 https://doi.org/10.1016/j.molcel.2020.11.001
|
|
BASE
|
|
Hide details
|
|
9 |
Desenvolvimento de uma versão portuguesa do nutritional risk screening NRS 2002
|
|
|
|
BASE
|
|
Show details
|
|
10 |
RELEASE: A protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia
|
|
|
|
BASE
|
|
Show details
|
|
11 |
Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0
|
|
|
|
BASE
|
|
Show details
|
|
12 |
Creation and analysis of biochemical constraint-based models: the COBRA Toolbox v3.0
|
|
|
|
BASE
|
|
Show details
|
|
14 |
Elastic constant determination of unidirectional composite via ultrasonic bulk wave through transmission measurements : a review
|
|
|
|
BASE
|
|
Show details
|
|
15 |
Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis: Fundamentals Of Care for UveitiS (FOCUS) Initiative.
|
|
|
|
In: Ophthalmology, vol. 125, no. 5, pp. 757-773 (2018)
|
|
BASE
|
|
Show details
|
|
17 |
A political ecology of REDD+ : Property rights, militarised protectionism, and carbonised exclusion in Cross River
|
|
|
|
BASE
|
|
Show details
|
|
18 |
COMMUNICATIVE AND COGNITIVE FEATURES OF ART DISCOURSE AND SCIENCE OF LANGUAGE
|
|
SEDYKH A.P.; KUGAN E.I.. - : Федеральное государственное автономное образовательное учреждение высшего профессионального образования «Белгородский государственный национальный исследовательский университет», 2015
|
|
BASE
|
|
Show details
|
|
19 |
Feasibility of automated speech sample collection with stuttering children using interactive voice response (IVR) technology
|
|
|
|
BASE
|
|
Show details
|
|
20 |
Comparability of Modern Recording Devices for Speech Analysis: Smartphone, Landline, Laptop, and Hard Disc Recorder
|
|
|
|
BASE
|
|
Show details
|
|
|
|