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Fighting and writing: journalists and the 1916 Easter Rising
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In: O'Brien, Mark (2018) Fighting and writing: journalists and the 1916 Easter Rising. Media History, 24 (3&4). pp. 350-363. ISSN 1368-8804 (2018)
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Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis.
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In: Human molecular genetics, vol 27, iss 24 (2018)
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Enrichment of genetic markers of recent human evolution in educational and cognitive traits.
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Srinivasan, Saurabh; Bettella, Francesco; Frei, Oleksandr; Hill, W David; Wang, Yunpeng; Witoelar, Aree; Schork, Andrew J; Thompson, Wesley K; Davies, Gail; Desikan, Rahul S; Deary, Ian J; Melle, Ingrid; Ueland, Torill; Dale, Anders M; Djurovic, Srdjan; Smeland, Olav B; Andreassen, Ole A
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In: Scientific reports, vol 8, iss 1 (2018)
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Abstract:
Higher cognitive functions are regarded as one of the main distinctive traits of humans. Evidence for the cognitive evolution of human beings is mainly based on fossil records of an expanding cranium and an increasing complexity of material culture artefacts. However, the molecular genetic factors involved in the evolution are still relatively unexplored. Here, we investigated whether genomic regions that underwent positive selection in humans after divergence from Neanderthals are enriched for genetic association with phenotypes related to cognitive functions. We used genome wide association data from a study of college completion (N = 111,114), one of educational attainment (N = 293,623) and two different studies of general cognitive ability (N = 269,867 and 53,949). We found nominally significant polygenic enrichment of associations with college completion (p = 0.025), educational attainment (p = 0.043) and general cognitive ability (p = 0.015 and 0.025, respectively), suggesting that variants influencing these phenotypes are more prevalent in evolutionarily salient regions. The enrichment remained significant after controlling for other known genetic enrichment factors, and for affiliation to genes highly expressed in the brain. These findings support the notion that phenotypes related to higher order cognitive skills typical of humans have a recent genetic component that originated after the separation of the human and Neanderthal lineages.
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Keyword:
Biochemistry and Cell Biology; Biological Evolution; Biotechnology; Brain; Clinical Research; Cognition; Educational Status; Female; Genetic Markers; Genetics; Genome; Genome-Wide Association Study; Human Genome; Humans; Intelligence; Male; Mental Health; Multifactorial Inheritance; Other Physical Sciences; Phenotype; Polymorphism; Single Nucleotide
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URL: https://escholarship.org/uc/item/1n9569p1
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Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
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In: Nature genetics, vol 50, iss 7 (2018)
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Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).
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In: Twin research and human genetics : the official journal of the International Society for Twin Studies, vol 21, iss 5 (2018)
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What's in a context? Cautions, limitations, and potential paths forward.
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Comparison studies on active cross-situational object-word learning using Non-Negative Matrix Factorization and Latent Dirichlet Allocation
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In: ISSN: 2379-8920 ; EISSN: 2379-8939 ; IEEE Transactions on Cognitive and Developmental Systems ; https://hal.archives-ouvertes.fr/hal-01561168 ; IEEE Transactions on Cognitive and Developmental Systems, Institute of Electrical and Electronics Engineers, Inc, In press, ⟨10.1109/TCDS.2017.2725304⟩ (2018)
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Central Auditory Processing Development in Primary School Children
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In: International Journal of Phonetics and Audiology ; https://hal.archives-ouvertes.fr/hal-01929254 ; International Journal of Phonetics and Audiology, Gavin Publishers, 2018, 2018 (1), ⟨10.29011/IJPA-102.100002⟩ ; https://www.gavinpublishers.com/articles/Research-Article/International-Journal-of-Phonetics-Audiology/Central-Auditory-Processing-Development-in-Primary-School-Children (2018)
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Do tigers confess? : an interdisciplinary study of confessionary evidence in counter-terrorism measures of Sri Lanka
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A COMPARISON OF SEMANTIC CONVERGENCE IN YOUNGER AND OLDER HINDI-ENGLISH BILINGUAL SPEAKERS ...
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Sharma, Nisha. - : Digital Repository at the University of Maryland, 2018
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Semantic and phonological schema influence spoken word learning and overnight consolidation. ...
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PSYCHOLINGUISTIC MEANINGS OF THE VERBALIZED CONCEPT "HOLY FOOL" (BASED ON THE RESULTS OF THE PSYCHOLINGUISTIC EXPERIMENT) ...
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Verbal Representation of the Concept "Church" (Based on the Association Test) ...
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PSYCHOLINGUISTIC MEANINGS OF THE VERBALIZED CONCEPT "HOLY FOOL" (BASED ON THE RESULTS OF THE PSYCHOLINGUISTIC EXPERIMENT) ...
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Verbal Representation of the Concept "Church" (Based on the Association Test) ...
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Exploring accounts of collaborative working between speech and language therapists and communication support coordinators following stroke
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Association Of National And Cultural Units In Uzbek Language ...
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Association Of National And Cultural Units In Uzbek Language ...
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СОПОСТАВЛЕНИЕ КОНЦЕПТУАЛЬНЫХ ПОЛЕЙ «БОГАТСТВО / БЕДНОСТЬ» В КИТАЙСКОЙ И РУССКОЙ ЛИНГВОКУЛЬТУРАХ: АНАЛИЗ РЕЗУЛЬТАТОВ АССОЦИАТИВНОГО ЭКСПЕРИМЕНТА И СОЦИОЛОГИЧЕСКОГО ОПРОСА ...
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