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Simple Search
Hits 1 – 15 of 15
1
Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant
Saracino, Dario
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Ferrieux, Sophie
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NOGUES-LASSIAILLE, Marie
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Houot, Marion
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FUNKIEWIEZ, Aurelie
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Sellami, Leila
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Deramecourt, Vincent
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Pasquier, Florence
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Couratier, Philippe
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PARIENTE, Jeremie
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GERAUDIE, Amandine
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Epelbaum, Stephane
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Wallon, David
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Hannequin, Didier
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Martinaud, Olivier
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Clot, Fabienne
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CAMUZAT, Agnes
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Bottani, Simona
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Rinaldi, Daisy
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Auriacombe, Sophie
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Sarazin, Marie
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Didic, Mira
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Boutoleau-Bretonnière, Claire
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Thauvin-Robinet, Christel
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Lagarde, Julien
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ROUE-JAGOT, Carole
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SELLAL, Francois
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Gabelle, Audrey
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ETCHARRY-BOUYX, Frederique
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Morin, Alexandre
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COPPOLA, Cinzia
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Levy, Richard
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Dubois, Bruno
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Brice, Alexis
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Colliot, Olivier
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GORNO-TEMPINI, Maria Luisa
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Teichmann, Marc
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Migliaccio, Raffaella
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Le Ber, Isabelle
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FRENCH RESEARCH NETWORK ON, Ftd Ftd-Als
In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021)
Abstract:
International audience ; OBJECTIVE: To determine relative frequencies and linguistic profiles of primary progressive aphasia (PPA) variants associated with progranulin (GRN) mutations, and study their neuroanatomical correlates. METHODS: PPA patients carrying GRN mutations (PPA-GRN) were selected amongst a national prospective research cohort of 1,696 frontotemporal dementia (FTD) patients, including 235 patients with PPA. All PPA patients with amyloid-positive CSF biomarkers were excluded. In this cross-sectional study, speech/language and cognitive profiles were characterized with standardized evaluations, and grey matter (GM) atrophy patterns using voxel-based morphometry. Comparisons were performed with controls, and sporadic PPA patients. RESULTS: Among the overall population of 235 patients, 45 (19%) carried GRN mutations. We studied 32 of these and showed that logopenic PPA (lvPPA) was the most frequent linguistic variant (13, 41%), followed by non-fluent/agrammatic (nfvPPA: 9, 28%) and mixed forms (8, 25%). Semantic variant was rather rare (2, 6%). LvPPA patients, qualified as non-amyloid-lvPPA, presented canonical logopenic deficit. Seven out of 13 had a pure form, six showed subtle additional linguistic deficits not fitting criteria for mixed PPA, hence labelled as "logopenic-spectrum variant". GM atrophy primarily involved left posterior temporal gyrus, mirroring neuroanatomical changes of amyloid-positive-lvPPA. NfvPPA patients presented agrammatism (89%) rather than apraxia of speech (11%). CONCLUSIONS: This study shows that most frequent PPA variant associated with GRN mutations is non-amyloid lvPPA, preceding nfvPPA and mixed forms, and illustrates that language network may be affected at different levels. GRN testing is indicated for PPA patients, whether familial or sporadic. This finding is important for upcoming GRN gene-specific therapies.
Keyword:
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
;
Dementia aphasia
;
Frontotemporal dementia
URL:
https://hal.archives-ouvertes.fr/hal-03281660/document
https://hal.archives-ouvertes.fr/hal-03281660/file/NEUROLOGY-2020-153064v3-LeBer.pdf
https://hal.archives-ouvertes.fr/hal-03281660
https://doi.org/10.1212/wnl.0000000000012174
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2
Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: the RELEASE database of aphasia after stroke
WILLIAMS, Louise R.
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ALI, Myzoon
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VANDENBERG, Kathryn
...
In: ISSN: 0268-7038 ; EISSN: 1464-5041 ; Aphasiology ; https://hal.archives-ouvertes.fr/hal-03528818 ; Aphasiology, Taylor & Francis (Routledge), 2021, ⟨10.1080/02687038.2021.1897081⟩ (2021)
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3
Relationships Between Anxiety Symptoms, Hopelessness and Suicidal Ideation Among Parental Caregivers of Mandarin-Speaking Children With Speech Impairment: The Mediating Effect of Depressive Symptoms
MA, Si-Wei
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LAI, Sha
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YANG, Yan-Yan
...
In: ISSN: 1664-0640 ; Frontiers in Psychiatry ; https://hal.archives-ouvertes.fr/hal-03323043 ; Frontiers in Psychiatry, Frontiers, 2021, 12, pp.648885. ⟨10.3389/fpsyt.2021.648885⟩ (2021)
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4
Predictors of Poststroke Aphasia Recovery: A Systematic Review-Informed Individual Participant Data Meta-Analysis
ALI, Myzoon
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VANDENBERG, Kathryn
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WILLIAMS, Linda J.
...
In: ISSN: 0039-2499 ; EISSN: 1524-4628 ; Stroke ; https://hal.archives-ouvertes.fr/hal-03277820 ; Stroke, American Heart Association, 2021, 52 (5), pp.1778-1787. ⟨10.1161/strokeaha.120.031162⟩ (2021)
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5
A systematic review of repetitive transcranial magnetic stimulation in aphasia rehabilitation: leads for future studies
ARHEIX-PARRAS, Sophie
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CASSOUDESALLE, Helene
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ENGELHARDT, Melanie
...
In: ISSN: 0149-7634 ; Neuroscience and Biobehavioral Reviews ; https://hal.archives-ouvertes.fr/hal-03267500 ; Neuroscience and Biobehavioral Reviews, Elsevier, 2021, 127, pp.212-241. ⟨10.1016/j.neubiorev.2021.04.008⟩ (2021)
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6
Similarities in cognitive abilities in older couples: a study of mutual influences ; : J Clin Exp Neuropsychol
CAILLOT-RANJEVA, Sybille
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Amieva, Helene
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MEILLON, Celine
...
In: ISSN: 1380-3395 ; EISSN: 1744-411X ; Journal of Clinical and Experimental Neuropsychology ; https://hal.archives-ouvertes.fr/hal-03188539 ; Journal of Clinical and Experimental Neuropsychology, Taylor & Francis (Routledge), 2021, pp.78-90. ⟨10.1080/13803395.2021.1874882⟩ (2021)
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7
Barriers and facilitators on hand hygiene and hydro-alcoholic solutions' use: representations of health professionals and prevention perspectives
CALCAGNI, Nicolas
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Venier, Anne-Gaelle
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NASSO, Raymond
...
In: ISSN: 2590-0889 ; Infection Prevention in Practice ; https://hal.archives-ouvertes.fr/hal-03610419 ; Infection Prevention in Practice, Elsevier, 2021, 3 (4), pp.100169. ⟨10.1016/j.infpip.2021.100169⟩ (2021)
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8
Behavior in childhood is associated with romantic partnering patterns in adulthood ; : J Child Psychol Psychiatry
VERGUNST, F.
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Zheng, Y.
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DOMOND, P.
...
In: ISSN: 1469-7610 ; Journal of Child Psychology and Psychiatry, and Allied Disciplines ; https://hal.archives-ouvertes.fr/hal-03173156 ; Journal of Child Psychology and Psychiatry, and Allied Disciplines, 2020, ⟨10.1111/jcpp.13329⟩ (2020)
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9
Cybervictimization in adolescence and its association with subsequent suicidal ideation/attempt beyond face-to-face victimization: a longitudinal population-based study ; : J Child Psychol Psychiatry
PERRET, L. C.
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ORRI, Massiliano
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Boivin, M.
...
In: ISSN: 0021-9630 ; EISSN: 1469-7610 ; Journal of Child Psychology and Psychiatry ; https://hal.archives-ouvertes.fr/hal-03138837 ; Journal of Child Psychology and Psychiatry, Wiley, In press, 61 (8), pp.866-874. ⟨10.1111/jcpp.13158⟩ (2020)
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10
Evolution of treatment paradigms in neovascular age-related macular degeneration: a review of real-world evidence
Daien, Vincent
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FINGER, R. P.
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TALKS, J. S.
...
In: ISSN: 0007-1161 ; EISSN: 1468-2079 ; British Journal of Ophthalmology ; https://hal.archives-ouvertes.fr/hal-03176168 ; British Journal of Ophthalmology, BMJ Publishing Group, 2020, ⟨10.1136/bjophthalmol-2020-317434⟩ (2020)
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11
Disability of people with aphasia is overestimated by general practitioners ; : Ann Phys Rehabil Med
Carlsberg, Mathilde
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PERCEY, Valentine
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ARHEIX-PARRAS, Sophie
...
In: ISSN: 1877-0657 ; Annals of Physical and Rehabilitation Medicine ; https://hal.archives-ouvertes.fr/hal-03166247 ; Annals of Physical and Rehabilitation Medicine, Elsevier Masson, 2020, 63 (3), pp.252-254. ⟨10.1016/j.rehab.2020.02.003⟩ (2020)
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12
NutriSem: A Semantics-Driven Approach to Calculating Nutritional Value of Recipes
Azzi, Rabia
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DESPRES, S
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Diallo, Gayo
In: Trends and Innovations in Information Systems and Technologies WorldCIST 2020. ; https://hal.archives-ouvertes.fr/hal-03108621 ; Rocha, Á; Adeli, H; Reis, L P; Costanzo, S; Orovic, I; Moreira, F. Trends and Innovations in Information Systems and Technologies WorldCIST 2020., 1159, Springer, pp.191-201, In press, 978-3-030-45688-7. ⟨10.1007/978-3-030-45688-7_20⟩ (2020)
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13
WIDGET: The WatriImed knowleDGe Exploration Tool ; : IST-Africa Conference
SOME, B. M. J.
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TEGUERA, Z.
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Traore, I.
...
In: 2020 IST-Africa Conference (IST-Africa) ; https://hal.archives-ouvertes.fr/hal-03144308 ; 2020 IST-Africa Conference (IST-Africa), May 2020, Kampala, Uganda (2020)
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14
Motor evoked potential of upper-limbs is predictive of aphasia recovery ; : Aphasiology
Glize, Bertrand
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Bigourdan, Antoine
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Villain, Marie
...
In: ISSN: 0268-7038 ; EISSN: 1464-5041 ; Aphasiology ; https://hal.archives-ouvertes.fr/hal-03210778 ; Aphasiology, Taylor & Francis (Routledge), 2019, 33 (1), pp.105-120. ⟨10.1080/02687038.2018.1444137⟩ (2019)
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15
Prenatal diet and children's trajectories of hyperactivity-inattention and conduct problems from 3 to 8 years: the EDEN mother-child cohort
Galéra, Cédric
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Heude, Barbara
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Forhan, Anne
...
In: ISSN: 0021-9630 ; EISSN: 1469-7610 ; Journal of Child Psychology and Psychiatry ; https://hal.inrae.fr/hal-02904871 ; Journal of Child Psychology and Psychiatry, Wiley, 2018, 59 (9), pp.1003-1011. ⟨10.1111/jcpp.12898⟩ (2018)
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