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Predictors of Poststroke Aphasia Recovery: A Systematic Review-Informed Individual Participant Data Meta-Analysis
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ALI, Myzoon; VANDENBERG, Kathryn; WILLIAMS, Linda J.; WILLIAMS, Louise R.; ABO, Masahiro; Becker, Frank; BOWEN, Audrey; BRANDENBURG, Caitlin; BREITENSTEIN, Caterina; BRUEHL, Stefanie; COPLAND, David A.; CRANFILL, Tamara B.; DI PIETRO-BACHMANN, Marie; ENDERBY, Pamela; FILLINGHAM, Joanne; GALLI, Federica Lucia; GANDOLFI, Marialuisa; Glize, Bertrand; GODECKE, Erin; Hawkins, Neil; HILARI, Katerina; HINCKLEY, Jacqueline; Horton, Simon; Howard, David; JAECKS, Petra; Jefferies, Elizabeth; JESUS, Luis M. T.; Kambanaros, Maria; KANG, Eun Kyoung; KHEDR, Eman M.; KONG, Anthony Pak-Hin; KUKKONEN, Tarja; Laganaro, Marina; RALPH, Matthew A. Lambon; LASKA, Ann Charlotte; LEEMANN, Beatrice; LEFF, Alexandre P.; LIMA, Roxele R.; Lorenz, Antje; MAC WHINNEY, Brian; MARSHALL, Rebecca Shisler; MEINZER, Marcus; NILIPOUR, Reza; NOE, Enrique; PAIK, Nam-Jong; PALMER, Rebecca; PAPATHANASIOU, Ilias; PATRICIO, Brigida F.; MARTINS, Isabel Pavao; PRICE, Cathy; JAKOVAC, Tatjana Prizl; ROCHON, Elizabeth; ROSE, Miranda L.; Rosso, Charlotte; RUBI-FESSEN, Ilona; RUITER, Marina B.; SNELL, Claerwen; STAHL, Benjamin; SZAFLARSKI, Jerzy P.; THOMAS, Shirley A.; VAN DE SANDT-KOENDERMAN, Mieke; VAN DER MEULEN, Ineke; VISCH-BRINK, Evy; WORRALL, Linda; WRIGHT, Heather Harris; BRADY, Marian C.; STROK, E. Release Collaborators
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In: ISSN: 0039-2499 ; EISSN: 1524-4628 ; Stroke ; https://hal.archives-ouvertes.fr/hal-03277820 ; Stroke, American Heart Association, 2021, 52 (5), pp.1778-1787. ⟨10.1161/strokeaha.120.031162⟩ (2021)
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Abstract:
Background and Purpose: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants' age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. Methods: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level. Results: Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4-165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3-26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (<55 years, +15.4 Western Aphasia Battery Aphasia-Quotient points [CI, 10.0-20.9], +6.1 correct on AAT Token Test [CI, 3.2-8.9]; +9.3 Boston Naming Test points [CI, 4.7-13.9]; +0.8 AAT Spontaneous-Speech Communication subscale points [CI, 0.5-1.0]) and enrollment <1 month post-onset (+19.1 Western Aphasia Battery Aphasia-Quotient points [CI, 13.9-24.4]; +5.3 correct on AAT Token Test [CI, 1.7-8.8]; +11.1 Boston Naming Test points [CI, 5.7-16.5]; and +1.1 AAT Spontaneous-Speech Communication subscale point [CI, 0.7-1.4]) conferred the greatest absolute change-from-baseline across each language domain. Improvements in language scores from baseline diminished with increasing age and aphasia chronicity. Data exhibited no significant statistical heterogeneity. Risk-of-bias was low to moderate-low. Conclusions: Earlier intervention for poststroke aphasia was crucial to maximize language recovery across a range of language domains, although recovery continued to be observed to a lesser extent beyond 6 months poststroke.
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Keyword:
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; Aphasia; Comprehension; Demography; Language; Survivor
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URL: https://hal.archives-ouvertes.fr/hal-03277820 https://doi.org/10.1161/strokeaha.120.031162
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Predictors of poststroke aphasia recovery: a systematic review-informed individual participant data meta-analysis
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