1 |
Cortical microstructure in primary progressive aphasia: a multicenter study.
|
|
|
|
In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
|
|
BASE
|
|
Show details
|
|
2 |
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
|
|
|
|
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
|
|
BASE
|
|
Show details
|
|
3 |
Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
|
|
|
|
BASE
|
|
Show details
|
|
4 |
What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
|
|
|
|
BASE
|
|
Show details
|
|
5 |
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
|
|
|
|
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
|
|
BASE
|
|
Show details
|
|
6 |
Automated profiling of spontaneous speech in primary progressive aphasia and behavioral-variant frontotemporal dementia: An approach based on usage-frequency
|
|
|
|
In: ISSN: 0010-9452 ; Cortex ; https://hal.archives-ouvertes.fr/hal-02993000 ; Cortex, Elsevier, 2020, 133, pp.103-119. ⟨10.1016/j.cortex.2020.08.027⟩ (2020)
|
|
BASE
|
|
Show details
|
|
7 |
New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
|
|
|
|
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
|
|
BASE
|
|
Show details
|
|
8 |
Amount and delay insensitivity during intertemporal choice in three neurodegenerative diseases reflects dorsomedial prefrontal atrophy.
|
|
|
|
BASE
|
|
Show details
|
|
9 |
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
|
|
|
|
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
|
|
BASE
|
|
Show details
|
|
10 |
Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
|
|
|
|
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
|
|
BASE
|
|
Show details
|
|
11 |
New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
|
|
|
|
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
|
|
BASE
|
|
Show details
|
|
12 |
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
|
|
|
|
BASE
|
|
Show details
|
|
13 |
Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia.
|
|
|
|
In: Brain : a journal of neurology, vol 143, iss 10 (2020)
|
|
BASE
|
|
Show details
|
|
14 |
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
|
|
|
|
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
|
|
BASE
|
|
Show details
|
|
15 |
Regional and hemispheric susceptibility of the temporal lobe to FTLD-TDP type C pathology.
|
|
Borghesani, V; Battistella, G; Mandelli, ML; Welch, A; Weis, E; Younes, K; Neuhaus, J; Grinberg, LT; Seeley, WM; Spina, S; Miller, B; Miller, Z; Gorno-Tempini, ML. - : eScholarship, University of California, 2020
|
|
Abstract:
Post-mortem studies show that focal anterior temporal lobe (ATL) neurodegeneration is most often caused by frontotemporal lobar degeneration TDP-43 type C pathology. Clinically, these patients are described with different terms, such as semantic variant primary progressive aphasia (svPPA), semantic dementia (SD), or right temporal variant frontotemporal dementia (FTD) depending on whether the predominant symptoms affect language, semantic knowledge for object or people, or socio-emotional behaviors. ATL atrophy presents with various degrees of lateralization, with right-sided cases considered rarer even though estimation of their prevalence is hampered by the paucity of studies on well-characterized, pathology-proven cohorts. Moreover, it is not clear whether left and right variants show a similar distribution of atrophy within the ATL cross-sectionally and longitudinally. Here we study the largest cohort to-date of pathology-proven TDP-43-C cases diagnosed during life as svPPA, SD or right temporal variant FTD. We analyzed clinical, cognitive, and neuroimaging data from 30 cases, a subset of which was followed longitudinally. Guided by recent structural and functional parcellation studies, we constructed four bilateral ATL regions of interest (ROIs). The computation of an atrophy lateralization index allowed the comparison of atrophy patterns between the two hemispheres. This led to an automatic, imaging-based classification of the cases as left-predominant or right-predominant. We then compared the two groups in terms of regional atrophy patterns within the ATL ROIs (cross-sectionally) and atrophy progression (longitudinally). Results showed that 40% of pathology proven cases of TDP-43-C diagnosed with a temporal variant presented with right-lateralized atrophy. Moreover, the findings of our ATL ROI analysis indicated that, irrespective of atrophy lateralization, atrophy distribution within both ATLs follows a medial-to-lateral gradient. Finally, in both left and right cases, atrophy appeared to progress to the contralateral ATL, and from the anterior temporal pole to posterior temporal and orbitofrontal regions. Taken together, our findings indicate that incipient right predominant ATL atrophy is common in TDP-43-C pathology, and that distribution of damage within the ATLs appears to be the same in left- and right- sided variants. Thus, regardless of differences in clinical phenotype and atrophy lateralization, both temporal variants of FTD should be viewed as a spectrum presentation of the same disease.
|
|
Keyword:
2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aging; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); Anterior temporal lobe; Atrophy; Brain Disorders; Clinical Research; Dementia; Frontotemporal Dementia; Frontotemporal Dementia (FTD); Frontotemporal Lobar Degeneration; FTLD-TDP type C; Humans; Magnetic Resonance Imaging; Neurodegenerative; Neuroimaging; Neurological; Neurosciences; Rare Diseases; Semantic dementia; Semantic variant Primary Progressive Aphasia; Temporal Lobe; Temporal variant
|
|
URL: https://escholarship.org/uc/item/4v9503mq
|
|
BASE
|
|
Hide details
|
|
16 |
Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
|
|
|
|
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
|
|
BASE
|
|
Show details
|
|
17 |
Amount and delay insensitivity during intertemporal choice in three neurodegenerative diseases reflects dorsomedial prefrontal atrophy.
|
|
|
|
BASE
|
|
Show details
|
|
18 |
Towards Understanding the Relationship between Language and Memory in Discourse
|
|
|
|
BASE
|
|
Show details
|
|
19 |
Factors that predict diagnostic stability in neurodegenerative dementia.
|
|
|
|
In: Journal of neurology, vol 266, iss 8 (2019)
|
|
BASE
|
|
Show details
|
|
20 |
Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia.
|
|
|
|
In: Alzheimer disease and associated disorders, vol 33, iss 3 (2019)
|
|
BASE
|
|
Show details
|
|
|
|