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Rapid tuning shifts in human auditory cortex enhance speech intelligibility.
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In: Nature communications, vol 7, iss 1 (2016)
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| 102 |
The auditory representation of speech sounds in human motor cortex.
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In: eLife, vol 5, iss MARCH2016 (2016)
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| 103 |
Rapid tuning shifts in human auditory cortex enhance speech intelligibility.
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In: Nature communications, vol 7, iss 1 (2016)
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| 104 |
Neuroanatomical anomalies of dyslexia: Disambiguating the effects of disorder, performance, and maturation.
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| 105 |
Effects of HIV and childhood trauma on brain morphometry and neurocognitive function.
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In: Journal of neurovirology, vol 22, iss 2 (2016)
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| 106 |
A human neurodevelopmental model for Williams syndrome.
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In: Nature, vol 536, iss 7616 (2016)
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| 107 |
Multivariate pattern classification of pediatric Tourette syndrome using functional connectivity MRI.
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In: Developmental science, vol 19, iss 4 (2016)
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| 108 |
A human neurodevelopmental model for Williams syndrome.
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In: Nature, vol 536, iss 7616 (2016)
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| 109 |
Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
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In: Brain imaging and behavior, vol 10, iss 1 (2016)
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| 110 |
Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
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In: Brain imaging and behavior, vol 10, iss 1 (2016)
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| 111 |
Natural speech reveals the semantic maps that tile human cerebral cortex.
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In: Nature, vol 532, iss 7600 (2016)
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| 112 |
Neuroeconomic dissociation of semantic dementia and behavioural variant frontotemporal dementia.
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In: Brain : a journal of neurology, vol 139, iss Pt 2 (2016)
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Abstract:
Many neuropsychiatric disorders are marked by abnormal behaviour and decision-making, but prevailing diagnostic criteria for such behaviours are typically qualitative and often ambiguous. Behavioural variant frontotemporal dementia and semantic variant primary progressive aphasia (also called semantic dementia) are two clinical variants of frontotemporal dementia with overlapping but distinct anatomical substrates known to cause profound changes in decision-making. We investigated whether abnormal decision-making in these syndromes could be more precisely characterized in terms of dissociable abnormalities in patients' subjective evaluations of valence (positive versus negative outcome) and of time (present versus future outcome). We presented 28 patients with behavioural variant frontotemporal dementia, 14 patients with semantic variant primary progressive aphasia, 25 patients with Alzheimer's disease (as disease controls), and 61 healthy older control subjects with experimental tasks assaying loss aversion and delay discounting. In general linear models controlling for age, gender, education and Mini-Mental State Examination score, patients with behavioural variant frontotemporal dementia were less averse to losses than control subjects (P < 0.001), while patients with semantic variant primary progressive aphasia discounted delayed rewards more steeply than controls (P = 0.019). There was no relationship between loss aversion and delay discounting across the sample, nor in any of the subgroups. These findings suggest that abnormal behaviours in neurodegenerative disease may result from the disruption of either of two dissociable neural processes for evaluating the outcomes of action. More broadly, these findings suggest a role for computational methods to supplement traditional qualitative characterizations in the differential diagnosis of neuropsychiatric disorders.
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Keyword:
2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aged; Aging; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Aphasia; behavioural neurology; Brain Disorders; Clinical Research; computational psychiatry; Decision Making; Dementia; Economics; Female; Frontotemporal Dementia; Frontotemporal Dementia (FTD); Humans; impulsivity and inhibition disorders; Male; Medical and Health Sciences; Mental Disorders; Mental Health; Middle Aged; Neurodegenerative; Neurological; Neurology & Neurosurgery; Neurosciences; Primary Progressive; Psychology and Cognitive Sciences; Psychomotor Performance; Rare Diseases; semantic dementia
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URL: https://escholarship.org/uc/item/9xz796qz
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| 113 |
Neural Correlates of Attention to Human-Made Sounds: An ERP Study.
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In: PloS one, vol 11, iss 10 (2016)
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| 114 |
Methods for acquiring MRI data in children with autism spectrum disorder and intellectual impairment without the use of sedation.
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In: Journal of neurodevelopmental disorders, vol 8, iss 1 (2016)
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| 115 |
Are Face and Object Recognition Independent? A Neurocomputational Modeling Exploration.
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In: Journal of cognitive neuroscience, vol 28, iss 4 (2016)
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| 116 |
Examining the contribution of motor movement and language dominance to increased left lateralization during sign generation in native signers
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In: Brain and Language , 159 pp. 109-117. (2016) (2016)
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| 117 |
Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing
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In: CEREBRAL CORTEX , 26 (11) pp. 4212-4226. (2016) (2016)
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| 119 |
Neural basis for processing hidden complexity indexed by small and finite clauses in Mandarin Chinese
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| 120 |
Dose Effect of Intratympanic Dexamethasone for Idiopathic Sudden Sensorineural Hearing Loss: 24 mg/mL Is Superior to 10 mg/mL.
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In: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, vol 36, iss 8 (2015)
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