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Rapid tuning shifts in human auditory cortex enhance speech intelligibility.
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In: Nature communications, vol 7, iss 1 (2016)
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| 102 |
The auditory representation of speech sounds in human motor cortex.
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In: eLife, vol 5, iss MARCH2016 (2016)
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| 103 |
Rapid tuning shifts in human auditory cortex enhance speech intelligibility.
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In: Nature communications, vol 7, iss 1 (2016)
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| 104 |
Neuroanatomical anomalies of dyslexia: Disambiguating the effects of disorder, performance, and maturation.
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Abstract:
An increasing body of studies has revealed neuroanatomical impairments in developmental dyslexia. However, whether these structural anomalies are driven by dyslexia (disorder-specific effects), absolute reading performance (performance-dependent effects), and/or further influenced by age (maturation-sensitive effects) remains elusive. To help disentangle these sources, the current study used a novel disorder (dyslexia vs. control) by maturation (younger vs. older) factorial design in 48 Chinese children who were carefully matched. This design not only allows for direct comparison between dyslexics versus controls matched for chronological age and reading ability, but also enables examination of the influence of maturation and its interaction with dyslexia. Voxel-based morphometry (VBM) showed that dyslexic children had reduced regional gray matter volume in the left temporo-parietal cortex (spanning over Heschl's gyrus, planum temporale and supramarginal gyrus), middle frontal gyrus, superior occipital gyrus, and reduced regional white matter in bilateral parieto-occipital regions (left cuneus and right precuneus) compared with both age-matched and reading-level matched controls. Therefore, maturational stage-invariant neurobiological signatures of dyslexia were found in brain regions that have been associated with impairments in the auditory/phonological and attentional systems. On the other hand, maturational stage-dependent effects on dyslexia were observed in three regions (left ventral occipito-temporal cortex, left dorsal pars opercularis and genu of the corpus callosum), all of which were previously reported to be involved in fluent reading and its development. These striking dissociations collectively suggest potential atypical developmental trajectories of dyslexia, where underlying mechanisms are currently unknown but may be driven by interactions between genetic and/or environmental factors. In summary, this is the first study to disambiguate maturational stage on neuroanatomical anomalies of dyslexia in addition to the effects of disorder, reading performance and maturational stage on neuroanatomical anomalies of dyslexia, despite the limitation of a relatively small sample-size. These results will hopefully encourage future research to place greater emphasis on taking a developmental perspective to dyslexia, which may, in turn, further our understanding of the etiological basis of this neurodevelopmental disorder, and ultimately optimize early identification and remediation.
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Keyword:
Adolescent; Analysis of Variance; Brain; Brain morphometry; Case-Control Studies; Child; Cognitive Sciences; Computer-Assisted; Developmental trajectories; Dyslexia; Etiology; Experimental Psychology; Female; Humans; Image Processing; Magnetic Resonance Imaging; Male; MRI; Neuropsychological Tests; Neurosciences; Nonparametric; Psychology; Statistics
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URL: https://escholarship.org/uc/item/28j9p46x
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| 105 |
Effects of HIV and childhood trauma on brain morphometry and neurocognitive function.
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In: Journal of neurovirology, vol 22, iss 2 (2016)
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| 106 |
A human neurodevelopmental model for Williams syndrome.
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In: Nature, vol 536, iss 7616 (2016)
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| 107 |
Multivariate pattern classification of pediatric Tourette syndrome using functional connectivity MRI.
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In: Developmental science, vol 19, iss 4 (2016)
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| 108 |
A human neurodevelopmental model for Williams syndrome.
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In: Nature, vol 536, iss 7616 (2016)
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| 109 |
Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
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In: Brain imaging and behavior, vol 10, iss 1 (2016)
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| 110 |
Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
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In: Brain imaging and behavior, vol 10, iss 1 (2016)
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| 111 |
Natural speech reveals the semantic maps that tile human cerebral cortex.
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In: Nature, vol 532, iss 7600 (2016)
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| 112 |
Neuroeconomic dissociation of semantic dementia and behavioural variant frontotemporal dementia.
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In: Brain : a journal of neurology, vol 139, iss Pt 2 (2016)
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| 113 |
Neural Correlates of Attention to Human-Made Sounds: An ERP Study.
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In: PloS one, vol 11, iss 10 (2016)
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| 114 |
Methods for acquiring MRI data in children with autism spectrum disorder and intellectual impairment without the use of sedation.
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In: Journal of neurodevelopmental disorders, vol 8, iss 1 (2016)
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| 115 |
Are Face and Object Recognition Independent? A Neurocomputational Modeling Exploration.
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In: Journal of cognitive neuroscience, vol 28, iss 4 (2016)
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| 116 |
Examining the contribution of motor movement and language dominance to increased left lateralization during sign generation in native signers
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In: Brain and Language , 159 pp. 109-117. (2016) (2016)
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| 117 |
Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing
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In: CEREBRAL CORTEX , 26 (11) pp. 4212-4226. (2016) (2016)
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| 119 |
Neural basis for processing hidden complexity indexed by small and finite clauses in Mandarin Chinese
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| 120 |
Dose Effect of Intratympanic Dexamethasone for Idiopathic Sudden Sensorineural Hearing Loss: 24 mg/mL Is Superior to 10 mg/mL.
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In: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, vol 36, iss 8 (2015)
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