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Rapid tuning shifts in human auditory cortex enhance speech intelligibility.
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In: Nature communications, vol 7, iss 1 (2016)
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| 102 |
The auditory representation of speech sounds in human motor cortex.
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In: eLife, vol 5, iss MARCH2016 (2016)
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| 103 |
Rapid tuning shifts in human auditory cortex enhance speech intelligibility.
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In: Nature communications, vol 7, iss 1 (2016)
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| 104 |
Neuroanatomical anomalies of dyslexia: Disambiguating the effects of disorder, performance, and maturation.
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| 105 |
Effects of HIV and childhood trauma on brain morphometry and neurocognitive function.
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In: Journal of neurovirology, vol 22, iss 2 (2016)
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| 106 |
A human neurodevelopmental model for Williams syndrome.
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In: Nature, vol 536, iss 7616 (2016)
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| 107 |
Multivariate pattern classification of pediatric Tourette syndrome using functional connectivity MRI.
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In: Developmental science, vol 19, iss 4 (2016)
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| 108 |
A human neurodevelopmental model for Williams syndrome.
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In: Nature, vol 536, iss 7616 (2016)
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| 109 |
Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
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In: Brain imaging and behavior, vol 10, iss 1 (2016)
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| 110 |
Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
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In: Brain imaging and behavior, vol 10, iss 1 (2016)
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| 111 |
Natural speech reveals the semantic maps that tile human cerebral cortex.
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In: Nature, vol 532, iss 7600 (2016)
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| 112 |
Neuroeconomic dissociation of semantic dementia and behavioural variant frontotemporal dementia.
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In: Brain : a journal of neurology, vol 139, iss Pt 2 (2016)
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| 113 |
Neural Correlates of Attention to Human-Made Sounds: An ERP Study.
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In: PloS one, vol 11, iss 10 (2016)
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| 114 |
Methods for acquiring MRI data in children with autism spectrum disorder and intellectual impairment without the use of sedation.
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In: Journal of neurodevelopmental disorders, vol 8, iss 1 (2016)
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| 115 |
Are Face and Object Recognition Independent? A Neurocomputational Modeling Exploration.
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In: Journal of cognitive neuroscience, vol 28, iss 4 (2016)
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| 116 |
Examining the contribution of motor movement and language dominance to increased left lateralization during sign generation in native signers
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In: Brain and Language , 159 pp. 109-117. (2016) (2016)
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| 117 |
Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing
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In: CEREBRAL CORTEX , 26 (11) pp. 4212-4226. (2016) (2016)
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| 119 |
Neural basis for processing hidden complexity indexed by small and finite clauses in Mandarin Chinese
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| 120 |
Dose Effect of Intratympanic Dexamethasone for Idiopathic Sudden Sensorineural Hearing Loss: 24 mg/mL Is Superior to 10 mg/mL.
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In: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, vol 36, iss 8 (2015)
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Abstract:
ObjectiveTo compare outcomes in patients with idiopathic sudden sensorineural hearing loss (ISSNHL) treated with intratympanic (IT) dexamethasone (DEX) at either 10 mg/mL or 24 mg/mL.Study designRetrospective case series.SettingTertiary referral center.PatientsThirty-seven adults with ISSNHL.InterventionsIn addition to concurrent prednisone taper, patients received a series of IT DEX injections for 2 weeks with either 10 mg/mL or 24 mg/mL.Main outcome measureGreater than 30-dB improvement in pure-tone average (PTA).ResultsBaseline characteristics were similar between groups. Mean follow-up was 10 weeks. Ten (53%) of 19 patients treated with 24 mg/mL had greater than 30-dB improvement in PTA compared with 3 (17%) of 18 treated with 10 mg/mL (p = 0.0382, Fisher's exact test). There was a trend toward improved word recognition score outcome with 24 mg/mL. The interval between onset and initiation of IT DEX significantly affected outcome, with earlier treatment resulting in greater improvement in PTA and word recognition score. Multivariate logistic regression confirmed that IT DEX dose and interval to starting treatment were both independent predictors of PTA outcome. Change in PTA was not significantly affected by age, sex, pretreatment hearing levels, or concurrent treatment with hyperbaric oxygen.ConclusionTo our knowledge, this is the first demonstration of superiority of IT DEX at 24 mg/mL for the treatment of ISSNHL, with significantly better recovery of PTA. Our data suggest that treatment should be initiated as soon as possible. A prospective randomized trial to confirm the optimal dose is warranted.
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Keyword:
6.1 Pharmaceuticals; Anti-Inflammatory Agents; Audiometry; Brain Disorders; Clinical Research; Clinical Sciences; Clinical Trials and Supportive Activities; Dexamethasone; Female; Hearing Loss; Humans; Hyperbaric Oxygenation; Idiopathic sudden sensorineural hearing loss; Injection; Intratympanic; Intratympanic dexamethasone; Male; Middle Aged; Neurosciences; Otorhinolaryngology; Pediatric; Prednisone; Prospective Studies; Public Health and Health Services; Pure-Tone; Retrospective Studies; Sensorineural; Speech Perception; Speech Reception Threshold Test; Sudden; Treatment Outcome; Tympanic Membrane; Zoology
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URL: https://escholarship.org/uc/item/4471c9qg
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