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41
The Relationship between Expressive Language Sampling and Clinical Measures in Fragile X Syndrome and Typical Development.
In: Brain sciences, vol 10, iss 2 (2020)
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42
Artificial intelligence approaches to predicting and detecting cognitive decline in older adults: A conceptual review.
Graham, Sarah A; Lee, Ellen E; Jeste, Dilip V. - : eScholarship, University of California, 2020
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43
Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019
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44
Physiological, behavioral and subjective sadness reactivity in frontotemporal dementia subtypes.
In: Social cognitive and affective neuroscience, vol 14, iss 12 (2019)
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45
Factors that predict diagnostic stability in neurodegenerative dementia.
In: Journal of neurology, vol 266, iss 8 (2019)
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46
Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia.
In: Alzheimer disease and associated disorders, vol 33, iss 3 (2019)
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47
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
Toller, Gianina; Yang, Winson FZ; Brown, Jesse A. - : eScholarship, University of California, 2019
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48
Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
Lee, Suzee E; Sias, Ana C; Kosik, Eena L. - : eScholarship, University of California, 2019
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49
Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.
In: Brain communications, vol 1, iss 1 (2019)
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50
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
Toller, Gianina; Yang, Winson FZ; Brown, Jesse A. - : eScholarship, University of California, 2019
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51
Physiological, behavioral and subjective sadness reactivity in frontotemporal dementia subtypes.
In: Social cognitive and affective neuroscience, vol 14, iss 12 (2019)
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52
Cortical encoding and decoding models of speech production
Chartier, Josh. - : eScholarship, University of California, 2019
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53
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
In: Scientific reports, vol 9, iss 1 (2019)
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54
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
In: Scientific reports, vol 9, iss 1 (2019)
Abstract: Accurate integration of sensory inputs and motor commands is essential to achieve successful behavioral goals. A robust model of sensorimotor integration is the pitch perturbation response, in which speakers respond rapidly to shifts of the pitch in their auditory feedback. In a previous study, we demonstrated abnormal sensorimotor integration in patients with Alzheimer's disease (AD) with an abnormally enhanced behavioral response topitch perturbation. Here we examine the neural correlates of the abnormal pitch perturbation response in AD patients, using magnetoencephalographic imaging. The participants phonated the vowel /α/ while a real-time signal processor briefly perturbed the pitch(100 cents, 400 ms) of their auditory feedback. We examined the high-gamma band (65-150 Hz) responses during this task. AD patients showed significantly reduced left prefrontal activity during the early phase of perturbation and increased right middle temporal activity during the later phase of perturbation, compared to controls. Activity in these brain regions significantly correlated with the behavioral response. These results demonstrate that impaired prefrontal modulation of speech-motor-control network and additional recruitment of right temporal regions are significant mediators of aberrant sensorimotor integration in patients with AD. The abnormal neural integration mechanisms signify the contribution of cortical network dysfunction to cognitive and behavioral deficits in AD.
Keyword: 2.1 Biological and endogenous factors; Acoustic Stimulation; Acquired Cognitive Impairment; Aging; Alzheimer Disease; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Basic Behavioral and Social Science; Behavioral and Social Science; Brain; Brain Disorders; Clinical Research; Dementia; Feedback; Female; Humans; Male; Middle Aged; Neurodegenerative; Neurological; Neurosciences; Phonation; Pitch Perception; Rehabilitation; Sensory; Speech
URL: https://escholarship.org/uc/item/3170w5cs
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55
Relationships Between Domain-Specific Cognition and Regional Brain Structure in a Typically Developing Cohort
Curley, Lauren Butler. - : eScholarship, University of California, 2019
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56
Linguistic and Cultural Acceptability of a Spanish Translation of the Ohio State University Traumatic Brain Injury Identification Method Among Community-Dwelling Spanish-Dominant Older Adults.
In: Archives of rehabilitation research and clinical translation, vol 1, iss 3-4 (2019)
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57
Muggle or magical?: Electrophysiological investigations of variation in the language-knowledge interface during reading
Troyer, Melissa. - : eScholarship, University of California, 2019
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58
A Randomized Controlled Trial of Sertraline in Young Children With Autism Spectrum Disorder.
Potter, Laura A; Scholze, Danielle A; Biag, Hazel Maridith B. - : eScholarship, University of California, 2019
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59
Pathogenic variants in USP7 cause a neurodevelopmental disorder with speech delays, altered behavior, and neurologic anomalies.
In: Genetics in medicine : official journal of the American College of Medical Genetics, vol 21, iss 8 (2019)
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60
A Randomized Controlled Trial of Sertraline in Young Children With Autism Spectrum Disorder.
Potter, Laura A; Scholze, Danielle A; Biag, Hazel Maridith B. - : eScholarship, University of California, 2019
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