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1
Shared space, separate processes: neural activation patterns for auditory description and visual object naming in healthy adults
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2
Examining the Multifactorial Nature of Cognitive Aging with Covariance Analysis of Positron Emission Tomography Data
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3
Examining the multifactorial nature of cognitive aging with covariance analysis of PET data
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4
Identification and Differential Vulnerability of a Neural Network in Sleep Deprivation
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Identification and Differential Vulnerability of a Neural Network in Sleep Deprivation ...
Abstract: The study aimed to identify task-related brain activation networks whose change in expression exhibits subject differences as a function of differential susceptibility to sleep deprivation. Brain activity during a non-verbal recognition memory task was investigated in an event-related functional MRI paradigm both prior to and after 48 h of sleep deprivation. Nineteen healthy subjects participated. Regional covariance analysis was applied to data. An activation network pattern was identified whose expression decreased from pre- to post-sleep deprivation in 15 out 19 subjects (P < 0.05). Differential decrease in expression correlated with worsening performance in recognition accuracy (P < 0.05). Sites of de-activation were found in the posterior cerebellum, right fusiform gyrus and precuneus, and left lingual and inferior temporal gyri; increased activation was found in the bilateral insula, claustrum and right putamen. A network whose expression decreased after sleep deprivation and correlated with ...
Keyword: Analysis of covariance; Cognition; Neural networks Neurobiology; Neurology; Sleep deprivation
URL: https://academiccommons.columbia.edu/doi/10.7916/D8KM0QBP
https://dx.doi.org/10.7916/d8km0qbp
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