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New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Evaluating follow-up and complexity in cancer clinical trials (EFACCT): an eDelphi study of research professionals' perspectives
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Abstract:
To evaluate patient follow-up and complexity in cancer clinical trial delivery, using consensus methods to: (1) identify research professionals' priorities, (2) understand localised challenges, (3) define study complexity and workloads supporting the development of a trial rating and complexity assessment tool (TRACAT). A classic eDelphi completed in three rounds, conducted as the launch study to a multiphase national project (evaluating follow-up and complexity in cancer clinical trials). Multicentre online survey involving professionals at National Health Service secondary care hospital sites in Scotland and England varied in scale, geographical location and patient populations. Principal investigators at 13 hospitals across nine clinical research networks recruited 33 participants using pre-defined eligibility criteria to form a multidisciplinary panel. Statements achieving a consensus level of 70% on a 7-point Likert-type scale and ranked trial rating indicators (TRIs) developed by research professionals. The panel developed 75 consensus statements illustrating factors contributing to complexity, follow-up intensity and operational performance in trial delivery, and specified 14 ranked TRIs. Seven open questions in the first qualitative round generated 531 individual statements. Iterative survey rounds returned rates of 82%, 82% and 93%. Clinical trials operate within a dynamic, complex healthcare and innovation system where rapid scientific advances present opportunities and challenges for delivery organisations and professionals. Panellists highlighted cultural and organisational factors limiting the profession's potential to support growing trial complexity and patient follow-up. Enhanced communication, interoperability, funding and capacity have emerged as key priorities. Future operational models should test dialectic Singerian-based approaches respecting open dialogue and shared values. Research capacity building should prioritise innovative, collaborative approaches embedding validated review and evaluation models to understand changing operational needs and challenges. TRACAT provides a mechanism for continual knowledge assimilation to improve decision-making. ; open access
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Keyword:
Clinical trials as topic
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URL: http://hdl.handle.net/10547/624073 https://doi.org/10.1136/bmjopen-2019-034269
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Collaborative Care for Depression among Patients with Limited English Proficiency: a Systematic Review.
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In: Journal of general internal medicine, vol 33, iss 3 (2018)
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A physician-initiated intervention to increase colorectal cancer screening in Chinese patients.
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In: Cancer, vol 124 Suppl 7, iss Suppl 7 (2018)
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A physician-initiated intervention to increase colorectal cancer screening in Chinese patients.
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A Breast Cancer Education Program for D/deaf Women.
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In: American annals of the deaf, vol 163, iss 2 (2018)
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Therapy and clinical trials in frontotemporal dementia: past, present, and future.
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In: Journal of neurochemistry, vol 138 Suppl 1, iss S1 (2016)
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Adaptation of a Cancer Clinical Trials Education Program for African American and Latina/o Community Members.
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In: Health education & behavior : the official publication of the Society for Public Health Education, vol 43, iss 4 (2016)
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Exercise for improving age-related hyperkyphotic posture: a systematic review.
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In: Archives of physical medicine and rehabilitation, vol 95, iss 1 (2014)
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Support from hospital to home for elders: a randomized trial.
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In: Annals of internal medicine, vol 161, iss 7 (2014)
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Making a decision about trial participation: the feasibility of measuring deliberation during the informed consent process for clinical trials.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef ; ORA review team (2014)
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New evidence for therapies in stroke rehabilitation.
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In: Current atherosclerosis reports, vol 15, iss 6 (2013)
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New evidence for therapies in stroke rehabilitation.
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In: Dobkin, Bruce H; & Dorsch, Andrew. (2013). New evidence for therapies in stroke rehabilitation. Current atherosclerosis reports, 15(6), 331. doi:10.1007/s11883-013-0331-y. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5ms0d9q0 (2013)
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Negotiating Participation in Oncology Clinical Trials for African Americans: Race, Identity, Power, and Barriers to Health ; Doctor of Philosophy
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The future of restorative neurosciences in stroke: driving the translational research pipeline from basic science to rehabilitation of people after stroke.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2009)
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Improving recruitment to clinical trials for cancer in childhood.
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In: Lancet Oncol , 9 (4) pp. 392-399. (2008) (2008)
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Improvement of the comprehension of written information given to healthy volunteers in biomedical research: a single-blind randomized controlled study.
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In: ISSN: 0767-3981 ; EISSN: 1472-8206 ; Fundamental and Clinical Pharmacology ; https://hal.archives-ouvertes.fr/hal-00281336 ; Fundamental and Clinical Pharmacology, Wiley, 2007, 21 (2), pp.207-14. ⟨10.1111/j.1472-8206.2007.00472.x⟩ (2007)
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Systematic review of abstinence-plus HIV prevention programs in high-income countries.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; CrossRef ; ORA review team (2007)
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Cross-cultural adaptation into Punjabi of the English version of the Hospital Anxiety and Depression Scale
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