1 |
The trans-ancestral genomic architecture of glycemic traits.
|
|
|
|
In: Nature genetics, vol. 53, no. 6, pp. 840-860 (2021)
|
|
BASE
|
|
Show details
|
|
2 |
Global genetic differentiation of complex traits shaped by natural selection in humans.
|
|
|
|
In: Nature communications, vol. 9, no. 1, pp. 1865 (2018)
|
|
Abstract:
There are mean differences in complex traits among global human populations. We hypothesize that part of the phenotypic differentiation is due to natural selection. To address this hypothesis, we assess the differentiation in allele frequencies of trait-associated SNPs among African, Eastern Asian, and European populations for ten complex traits using data of large sample size (up to ~405,000). We show that SNPs associated with height ([Formula: see text]), waist-to-hip ratio ([Formula: see text]), and schizophrenia ([Formula: see text]) are significantly more differentiated among populations than matched "control" SNPs, suggesting that these trait-associated SNPs have undergone natural selection. We further find that SNPs associated with height ([Formula: see text]) and schizophrenia ([Formula: see text]) show significantly higher variance in linkage disequilibrium (LD) scores across populations than control SNPs. Our results support the hypothesis that natural selection has shaped the genetic differentiation of complex traits, such as height and schizophrenia, among worldwide populations.
|
|
Keyword:
African Continental Ancestry Group; Alleles; Asian Continental Ancestry Group; Body Height; European Continental Ancestry Group; Gene Frequency; Genetic; Genome; Genome-Wide Association Study; Heritable; Human; Humans; Linkage Disequilibrium; Phenotype; Polymorphism; Quantitative Trait; Quantitative Trait Loci; Sample Size; Schizophrenia/ethnology; Schizophrenia/genetics; Schizophrenia/pathology; Selection; Single Nucleotide; Waist-Hip Ratio
|
|
URL: https://serval.unil.ch/resource/serval:BIB_CF8AC0B8B126.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_CF8AC0B8B1266 https://serval.unil.ch/notice/serval:BIB_CF8AC0B8B126 https://doi.org/10.1038/s41467-018-04191-y
|
|
BASE
|
|
Hide details
|
|
3 |
Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.
|
|
|
|
In: Mol Psychiatry , 19 (2) 253 - 258. (2014) (2014)
|
|
BASE
|
|
Show details
|
|
4 |
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2009)
|
|
BASE
|
|
Show details
|
|
5 |
Generalist genes and the Internet generation: etiology of learning abilities by web testing at age 10.
|
|
|
|
In: Genes Brain Behav , 7 (4) pp. 455-462. (2008) (2008)
|
|
BASE
|
|
Show details
|
|
6 |
Heritable risk factors associated with language impairments.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef ; ORA review team (2007)
|
|
BASE
|
|
Show details
|
|
7 |
A genomewide scan identifies two novel loci involved in specific language impairment.
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; ORA review team (2002)
|
|
BASE
|
|
Show details
|
|
8 |
Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2002)
|
|
BASE
|
|
Show details
|
|
9 |
A quantitative-trait locus on chromosome 6p influences different aspects of developmental dyslexia.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (1999)
|
|
BASE
|
|
Show details
|
|
10 |
A genome-wide search strategy for identifying quantitative trait loci involved in reading and spelling disability (developmental dyslexia).
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (1999)
|
|
BASE
|
|
Show details
|
|
|
|