Page: 1 2 3 4 5 6 7 8... 29
61 |
Assessing and mapping language, attention and executive multidimensional deficits in stroke aphasia. ...
|
|
|
|
BASE
|
|
Show details
|
|
62 |
The neural systems supporting human intelligence, as measured by lesion analysis, task activation, and resting state connectivity
|
|
|
|
BASE
|
|
Show details
|
|
63 |
Paracingulate Sulcus Morphology and Hallucinations in Clinical and Nonclinical Groups.
|
|
|
|
BASE
|
|
Show details
|
|
64 |
Domain-general and domain-specific computations in single word processing.
|
|
|
|
BASE
|
|
Show details
|
|
65 |
Assessing and mapping language, attention and executive multidimensional deficits in stroke aphasia.
|
|
|
|
BASE
|
|
Show details
|
|
66 |
Balancing Prediction and Sensory Input in Speech Comprehension: The Spatiotemporal Dynamics of Word Recognition in Context.
|
|
|
|
BASE
|
|
Show details
|
|
67 |
Increased cortical reactivity to repeated tones at 8 months in infants with later ASD.
|
|
|
|
BASE
|
|
Show details
|
|
68 |
Differential language network functional connectivity alterations in Alzheimer's disease and the semantic variant of primary progressive aphasia
|
|
|
|
BASE
|
|
Show details
|
|
69 |
Relación entre destreza musical y lateralización derecha del lenguaje en población zurda
|
|
|
|
BASE
|
|
Show details
|
|
70 |
Anomalous morphology in left hemisphere motor and premotor cortex of children who stutter
|
|
|
|
BASE
|
|
Show details
|
|
71 |
Anterior insular thickness predicts speech sound learning ability in bilinguals.
|
|
|
|
In: NeuroImage, vol 165 (2018)
|
|
BASE
|
|
Show details
|
|
72 |
Evidence Supporting LI-RADS Major Features for CT- and MR Imaging-based Diagnosis of Hepatocellular Carcinoma: A Systematic Review.
|
|
|
|
In: Radiology, vol 286, iss 1 (2018)
|
|
BASE
|
|
Show details
|
|
73 |
Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
|
|
Santos-Santos, Miguel A; Rabinovici, Gil D; Iaccarino, Leonardo; Ayakta, Nagehan; Tammewar, Gautam; Lobach, Iryna; Henry, Maya L; Hubbard, Isabel; Mandelli, Maria Luisa; Spinelli, Edoardo; Miller, Zachary A; Pressman, Peter S; O'Neil, James P; Ghosh, Pia; Lazaris, Andreas; Meyer, Marita; Watson, Christa; Yoon, Soo Jin; Rosen, Howard J; Grinberg, Lea; Seeley, William W; Miller, Bruce L; Jagust, William J; Gorno-Tempini, Maria Luisa
|
|
In: JAMA neurology, vol 75, iss 3 (2018)
|
|
Abstract:
Importance:The ability to predict the pathology underlying different neurodegenerative syndromes is of critical importance owing to the advent of molecule-specific therapies. Objective:To determine the rates of positron emission tomography (PET) amyloid positivity in the main clinical variants of primary progressive aphasia (PPA). Design, Setting, and Participants:This prospective clinical-pathologic case series was conducted at a tertiary research clinic specialized in cognitive disorders. Patients were evaluated as part of a prospective, longitudinal research study between January 2002 and December 2015. Inclusion criteria included clinical diagnosis of PPA; availability of complete speech, language, and cognitive testing; magnetic resonance imaging performed within 6 months of the cognitive evaluation; and PET carbon 11-labeled Pittsburgh Compound-B or florbetapir F 18 brain scan results. Of 109 patients referred for evaluation of language symptoms who underwent amyloid brain imaging, 3 were excluded because of incomplete language evaluations, 5 for absence of significant aphasia, and 12 for presenting with significant initial symptoms outside of the language domain, leaving a cohort of 89 patients with PPA. Main Outcomes and Measures:Clinical, cognitive, neuroimaging, and pathology results. Results:Twenty-eight cases were classified as imaging-supported semantic variant PPA (11 women [39.3%]; mean [SD] age, 64 [7] years), 31 nonfluent/agrammatic variant PPA (22 women [71.0%]; mean [SD] age, 68 [7] years), 26 logopenic variant PPA (17 women [65.4%]; mean [SD] age, 63 [8] years), and 4 mixed PPA cases. Twenty-four of 28 patients with semantic variant PPA (86%) and 28 of 31 patients with nonfluent/agrammatic variant PPA (90%) had negative amyloid PET scan results, while 25 of 26 patients with logopenic variant PPA (96%) and 3 of 4 mixed PPA cases (75%) had positive scan results. The amyloid positive semantic variant PPA and nonfluent/agrammatic variant PPA cases with available autopsy data (2 of 4 and 2 of 3, respectively) all had a primary frontotemporal lobar degeneration and secondary Alzheimer disease pathologic diagnoses, whereas autopsy of 2 patients with amyloid PET-positive logopenic variant PPA confirmed Alzheimer disease. One mixed PPA patient with a negative amyloid PET scan had Pick disease at autopsy. Conclusions and Relevance:Primary progressive aphasia variant diagnosis according to the current classification scheme is associated with Alzheimer disease biomarker status, with the logopenic variant being associated with carbon 11-labeled Pittsburgh Compound-B positivity in more than 95% of cases. Furthermore, in the presence of a clinical syndrome highly predictive of frontotemporal lobar degeneration pathology, biomarker positivity for Alzheimer disease may be associated more with mixed pathology rather than primary Alzheimer disease.
|
|
Keyword:
Aged; Amyloid; Aniline Compounds; Aphasia; Brain; Ethylene Glycols; Female; Humans; Imaging; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Primary Progressive; Retrospective Studies; Severity of Illness Index; Thiazoles; Three-Dimensional
|
|
URL: https://escholarship.org/uc/item/1hm128x5
|
|
BASE
|
|
Hide details
|
|
74 |
Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
|
|
|
|
In: JAMA neurology, vol 75, iss 3 (2018)
|
|
BASE
|
|
Show details
|
|
75 |
Neuroscientific insights into the development of analogical reasoning.
|
|
|
|
In: Developmental science, vol 21, iss 2 (2018)
|
|
BASE
|
|
Show details
|
|
76 |
Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.
|
|
|
|
In: Nature neuroscience, vol 21, iss 12 (2018)
|
|
BASE
|
|
Show details
|
|
77 |
Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.
|
|
|
|
In: Nature neuroscience, vol 21, iss 12 (2018)
|
|
BASE
|
|
Show details
|
|
78 |
Brain basis of cognitive resilience: Prefrontal cortex predicts better reading comprehension in relation to decoding.
|
|
|
|
In: PloS one, vol 13, iss 6 (2018)
|
|
BASE
|
|
Show details
|
|
79 |
Dynamic integration of conceptual information during learning.
|
|
|
|
In: PloS one, vol 13, iss 11 (2018)
|
|
BASE
|
|
Show details
|
|
80 |
Use of Vitamin K Antagonists and Brain Morphological Changes in Older Adults: An Exposed/Unexposed Voxel-Based Morphometric Study
|
|
|
|
In: ISSN: 1421-9824 ; Dementia and geriatric cognitive disorders ; https://hal.univ-angers.fr/hal-02869144 ; Dementia and geriatric cognitive disorders, 2018, 45, pp.18-26. ⟨10.1159/000485793⟩ ; https://www.karger.com/Article/Abstract/485793 (2018)
|
|
BASE
|
|
Show details
|
|
Page: 1 2 3 4 5 6 7 8... 29
|
|