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1
Auditory object cognition in dementia
In: Neuropsychologia , 49 (9) 2755 - 2765. (2011) (2011)
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2
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
In: BRAIN , 134 2456 - 2477. (2011) (2011)
Abstract: Based on the recent literature and collective experience, an international consortium developed revised guidelines for the diagnosis of behavioural variant frontotemporal dementia. The validation process retrospectively reviewed clinical records and compared the sensitivity of proposed and earlier criteria in a multi-site sample of patients with pathologically verified frontotemporal lobar degeneration. According to the revised criteria, 'possible' behavioural variant frontotemporal dementia requires three of six clinically discriminating features (disinhibition, apathy/inertia, loss of sympathy/empathy, perseverative/compulsive behaviours, hyperorality and dysexecutive neuropsychological profile). 'Probable' behavioural variant frontotemporal dementia adds functional disability and characteristic neuroimaging, while behavioural variant frontotemporal dementia 'with definite frontotemporal lobar degeneration' requires histopathological confirmation or a pathogenic mutation. Sixteen brain banks contributed cases meeting histopathological criteria for frontotemporal lobar degeneration and a clinical diagnosis of behavioural variant frontotemporal dementia, Alzheimer's disease, dementia with Lewy bodies or vascular dementia at presentation. Cases with predominant primary progressive aphasia or extra-pyramidal syndromes were excluded. In these autopsy-confirmed cases, an experienced neurologist or psychiatrist ascertained clinical features necessary for making a diagnosis according to previous and proposed criteria at presentation. Of 137 cases where features were available for both proposed and previously established criteria, 118 (86%) met 'possible' criteria, and 104 (76%) met criteria for 'probable' behavioural variant frontotemporal dementia. In contrast, 72 cases (53%) met previously established criteria for the syndrome (P < 0.001 for comparison with 'possible' and 'probable' criteria). Patients who failed to meet revised criteria were significantly older and most had atypical presentations with marked memory impairment. In conclusion, the revised criteria for behavioural variant frontotemporal dementia improve diagnostic accuracy compared with previously established criteria in a sample with known frontotemporal lobar degeneration. Greater sensitivity of the proposed criteria may reflect the optimized diagnostic features, less restrictive exclusion features and a flexible structure that accommodates different initial clinical presentations. Future studies will be needed to establish the reliability and specificity of these revised diagnostic guidelines.
Keyword: ALZHEIMERS-DISEASE; behavioural variant frontotemporal dementia; CEREBRAL-BLOOD-FLOW; diagnostic criteria; FRONTAL ASSESSMENT BATTERY; frontotemporal lobar degeneration; FTD; LOBAR DEGENERATION; NEURODEGENERATIVE DISEASE; NEUROPSYCHIATRIC SYMPTOMS; pathology; PICKS-DISEASE; SEMANTIC DEMENTIA; TEMPORAL VARIANTS; VASCULAR DEMENTIA
URL: http://discovery.ucl.ac.uk/1325627/
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3
Voice processing in dementia: a neuropsychological and neuroanatomical analysis
In: BRAIN , 134 2535 - 2547. (2011) (2011)
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4
Flavour processing in semantic dementia
In: CORTEX , 46 (6) 761 - 768. (2010) (2010)
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5
Measuring disease progression in frontotemporal lobar degeneration A clinical and MRI study
In: NEUROLOGY , 74 (8) 666 - 673. (2010) (2010)
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6
Progranulin-associated primary progressive aphasia: A distinct phenotype?
In: NEUROPSYCHOLOGIA , 48 (1) 288 - 297. (2010) (2010)
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7
Progressive logopenic/phonological aphasia: Erosion of the language network
In: NEUROIMAGE , 49 (1) 984 - 993. (2010) (2010)
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8
Syndromes of nonfluent primary progressive aphasia A clinical and neurolinguistic analysis
In: NEUROLOGY , 75 (7) 603 - 610. (2010) (2010)
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9
Abnormal laughter-like vocalisations replacing speech in primary progressive aphasia
In: J NEUROL SCI , 284 (1-2) 120 - 123. (2009) (2009)
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10
Patterns of cortical thinning in the language variants of frontotemporal lobar degeneration
In: NEUROLOGY , 72 (18) 1562 - 1569. (2009) (2009)
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11
Tracking progression in frontotemporal lobar degeneration Serial MRI in semantic dementia
In: NEUROLOGY , 71 (18) 1445 - 1451. (2008) (2008)
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12
Mapping the progression of progranulin-associated frontotemporal lobar degeneration
In: NAT CLIN PRACT NEURO , 4 (8) 455 - 460. (2008) (2008)
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13
Word-finding difficulty: a clinical analysis of the progressive aphasias
In: BRAIN , 131 8 - 38. (2008) (2008)
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