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Functional Connectivity and Speech Entrainment Speech Entrainment Improves Connectivity Between Anterior and Posterior Cortical Speech Areas in Non-fluent Aphasia ...
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Functional Connectivity and Speech Entrainment Speech Entrainment Improves Connectivity Between Anterior and Posterior Cortical Speech Areas in Non-fluent Aphasia ...
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Speech Entrainment Improves Connectivity Between Anterior and Posterior Cortical Speech Areas in Non-Fluent Aphasia
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In: Neurorehabil Neural Repair (2022)
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Isolating the white matter circuitry of the dorsal language stream: Connectome‐Symptom Mapping in stroke induced aphasia
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In: Hum Brain Mapp (2021)
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Independent contributions of structural and functional connectivity: Evidence from a stroke model
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In: Netw Neurosci (2021)
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2018 ASHA Research Symposium: Julius Fridricksson, BDNF Genotype & Brain Activation in Aphasia ...
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2018 ASHA Research Symposium: Julius Fridricksson, BDNF Genotype & Brain Activation in Aphasia ...
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Machine learning‐based multimodal prediction of language outcomes in chronic aphasia
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In: Hum Brain Mapp (2020)
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2018 ASHA Research Symposium: Julius Fridricksson, BDNF Genotype & Brain Activation in Aphasia ...
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BDNF genotype & brain activation in aphasia (Kristinsson et al., 2019) ...
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BDNF genotype & brain activation in aphasia (Kristinsson et al., 2019) ...
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Progression of Aphasia Severity in the Chronic Stages of Stroke
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Leukoaraiosis is associated with a decline in language abilities in chronic aphasia
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In: Neurorehabil Neural Repair (2019)
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Cortical and structural-connectivity damage correlated with impaired syntactic processing in aphasia
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Brain-Derived Neurotrophic Factor Genotype–Specific Differences in Cortical Activation in Chronic Aphasia
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Predicting Recovery in Acute Post-stroke Aphasia
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Hillis, Argye E.; Beh, Yuan Ye; Sebastian, Rajani; Breining, Bonnie; Tippett, Donna C.; Wright, Amy; Saxena, Sadhvi; Rorden, Chris; Bonilha, Leonardo; Basilakos, Alexandra; Yourganov, Grigori; Fridriksson, Julius. - 2018
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Abstract:
OBJECTIVE: Many stroke patients show remarkable recovery of language after initial severe impairment, but it is difficult to predict which patients will show good recovery. We aimed to identify patient and lesion characteristics that together predict the best naming outcome in four studies. METHODS: We report two longitudinal studies that identified two variables at onset that were strongly associated with good recovery of naming (the most common residual deficit in aphasia) in the first six months after stroke: damage to left posterior superior temporal gyrus (pSTG) and/or superior longitudinal fasciculus/arcuate fasciculus (SLF/AF) and selective serotonin reuptake inhibitor (SSRI) use. We then tested these variables in two independent cohorts of chronic left hemisphere stroke patients, using chi squared tests and multivariable logistic regression for dichotomous outcomes and t-tests for continuous outcomes. RESULTS: Lesion load in left pSTG and SLF/AF was associated with poorer naming outcome. Preservation of these areas and use of SSRIs were associated with naming recovery, independent of lesion volume, time since stroke, and depression. Patients with damage to these critical areas showed better naming outcome if they took SSRIs for three months after stroke. Those with preservation of these critical areas achieved good recovery of naming regardless of SSRI use. INTERPRETATION: Lesion load in left pSTG and SLF/AF at onset predicts later naming performance. Although based on a small number of patients, our preliminary results suggest outcome might be modulated by SSRIs, but these associations need to be confirmed in a larger randomized controlled trial.
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Keyword:
Article
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URL: https://doi.org/10.1002/ana.25184 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867273/ http://www.ncbi.nlm.nih.gov/pubmed/29451321
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